Association between the triglyceride-glucose index and diabetic nephropathy in patients with type 2 diabetes: A cross-sectional study.
Association between the triglyceride-glucose index and diabetic nephropathy in patients with type 2 diabetes: A cross-sectional study.
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2 型糖尿病患者甘油三酯-葡萄糖指数与糖尿病肾病之间的关联：一项横断面研究
DOI：
10.1111/jdi.13371
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发表时间：
2021-04
影响因子：
3.2
通讯作者：
Yuan G
中科院分区：
文献类型：
--
作者：
Liu L;Xia R;Song X;Zhang B;He W;Zhou X;Li S;Yuan G
胰岛素-葡萄糖（TyG）指数已被提出作为胰岛素抵抗的可靠和简单的标志物。我们研究了2型糖尿病患者TyG指数与糖尿病肾病（DN）的关系。本横断面分析纳入了2007年1月至2009年12月在同济医院（中国湖北省武汉市）内分泌科住院的682例2型糖尿病成人患者的连续病例系列。进行受试者操作特征曲线分析、相关分析和多元逻辑回归分析。共有232名（34.0%）参与者被确定为DN。与非DN组相比，DN组病程较长，体重、收缩压、舒张压、糖化血红蛋白、甘油三酯、总胆固醇、血尿酸、24 h尿白蛋白、TyG指数和稳态模型评估2胰岛素抵抗估计值（HOMA 2-IR;均P < 0.05）较高。在DN识别的受试者工作特征曲线分析中，最佳临界点>9.66的TyG指数显示出更高的受试者工作特征曲线下面积0.67（P = 0.002），高于HOMA 2-IR（曲线下面积0.61，P = 0.029）。此外，TyG指数与代谢指标（体重、糖化血红蛋白、甘油三酯、总胆固醇、血清尿酸、空腹血糖和HOMA 2-IR）和24 h尿白蛋白的自然对数水平呈正相关（各P < 0.05），但与估计肾小球滤过率的自然对数无关。多元回归分析显示，TyG指数升高是DN的独立危险因素（比值比1.91，P = 0.001）。TyG指数与2型糖尿病患者的DN独立相关，是一个比HOMA 2-IR更好的识别2型糖尿病患者DN的标志物。胰岛素-葡萄糖指数为监测胰岛素抵抗程度提供了一种负担得起且易于解释的生物标志物，并且与2型糖尿病患者的糖尿病肾病独立相关。与稳态模型胰岛素抵抗评估相比，它是一种更好的2型糖尿病肾病诊断指标。
The triglyceride–glucose (TyG) index has been proposed as a reliable and simple marker of insulin resistance. We investigated the association between TyG index and diabetic nephropathy (DN) in patients with type 2 diabetes. A consecutive case series of 682 adult patients with type 2 diabetes hospitalized in the Department of Endocrinology at the Tongji Hospital (Wuhan, Hubei, China) from January 2007 to December 2009 was included in this cross‐sectional analysis. Receiver operating characteristics curve analysis, correlation analysis and multiple logistic regression analysis were carried out. A total of 232 (34.0%) participants were identified with DN. Compared with the non‐DN group, the DN group had longer disease duration, and higher bodyweight, systolic blood pressure, diastolic blood pressure, glycated hemoglobin, triglycerides, total cholesterol, serum uric acid, 24 h‐urinary albumin, TyG index and homeostasis model assessment 2 estimates for insulin resistance (HOMA2‐IR; P < 0.05 for each). The TyG index with an optimal cut‐off point >9.66 showed a higher area under the receiver operating characteristic curve of 0.67 (P = 0.002) than HOMA2‐IR (area under the curve 0.61, P = 0.029) on receiver operating characteristic curve analysis for DN identification. Additionally, the TyG index positively correlated with the levels of metabolic indicators (bodyweight, glycated hemoglobin, triglycerides, total cholesterol, serum uric acid, fasting glucose and HOMA2‐IR) and natural logarithmic 24 h‐urinary albumin (P < 0.05 for each), but not natural logarithm of estimated glomerular filtration rate. On multiple regression analysis, an increased TyG index was shown to be an independent risk factor (odds ratio 1.91, P = 0.001) for DN. The TyG index was independently associated with DN in patients with type 2 diabetes, and was a better marker than HOMA2‐IR for identification of DN in type 2 diabetes patients. The triglyceride–glucose index provides an affordable and easily interpreted biomarker for monitoring the degree of insulin resistance, and was independently associated with diabetic nephropathy in patients with type 2 diabetes. It was a better marker than homeostasis model assessment for insulin resistance for identification of diabetic nephropathy in type 2 diabetes patients.
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影响因子：
16.2
作者：
Hsu CC;Chang HY;Huang MC;Hwang SJ;Yang YC;Tai TY;Yang HJ;Chang CT;Chang CJ;Li YS;Shin SJ;Kuo KN
通讯作者：
Kuo KN
影响因子：
3.2
作者：
Li R;Li Q;Cui M;Yin Z;Li L;Zhong T;Huo Y;Xie P
通讯作者：
Xie P
影响因子：
4.9
作者：
Kang, B.;Yang, Y.;Yoon, K-H
通讯作者：
Yoon, K-H
影响因子：
4.4
作者：
Jin, Jing-Lu;Sun, Di;Li, Jian-Jun
通讯作者：
Li, Jian-Jun
影响因子：
19.6
作者：
Dominguez, JH;Tang, NJ;Peterson, R
通讯作者：
Peterson, R