GalT-KO pigs: is the cup half empty or half full?
GalT-KO pigs: is the cup half empty or half full?
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GalT-KO猪：杯子是半空还是半满？
DOI：
10.1097/01.tp.0000269729.68625.08
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发表时间：
2007
期刊：
影响因子：
6.2
通讯作者：
Sykes,Megan
中科院分区：
文献类型：
--
作者：
Sachs,DavidH;Yamada,Kazuhiko;Robson,SimonC;Fishman,JayA;Shimizu,Akira;Colvin,RobertB;Sykes,Megan
In their timely overview on the importance of the α1, 3-galactosyltransferase gene-knockout (GalT-KO) pig to the future of organ xenotransplantation, Cooper et al. have painted a picture of the field as a cup “half empty.” While they have appropriately identified tolerance as the ultimate goal for these studies, there appears to be a logical flaw in their conclusion that major problems, particularly of the coagulation system, will need to be overcome before tolerance can be achieved. In our eyes, the current assessment should rather be that of a cup “half full,” with the problems they have described occurring when tolerance was not achieved. Because the organ xenotransplant data on which their commentary was based were generated largely in this research center, we would like to take this opportunity to revise some of their interpretations.Cooper et al. suggest that the microangiopathy observed in the cited studies of xenografted hearts and kidneys is likely to be the main barrier to successful organ xenotransplantation. However, in the majority of these studies, xenograft recipients were treated with prolonged immunosuppression rather than with regimens directed toward tolerance induction. In the single study cited in which the goal was tolerance induction (1), the xenografts showed little if any evidence of the microangiopathy that was so prevalent in hearts and kidneys prolonged by immunosuppressive drugs alone. Furthermore, in the setting of tolerance induction strategies, life-supporting kidneys continued to function without evidence of rejection for prolonged periods when compared to previously reported xenograft kidneys from other strains of pigs or even to GalT-KO pigs transplanted without a regimen directed toward tolerance induction. What is the implication of these observations? Cooper et al. claim that “cellular infiltrates in GalT-KO grafts have been sparse or nonexistent, suggesting that the T-cell effector
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影响因子：
82.9
作者：
Yamada, K;Yazawa, K;Sachs, DH
通讯作者：
Sachs, DH
猪巨细胞病毒和猪灵长类异种移植中的凝血病1
影响因子：
6.2
作者：
B. Gollackner;N. Mueller;S. Houser;I. Qawi;Daniel Soizic;C. Knosalla;L. Buhler;F. Dor;M. Awwad;D. Sachs;D. Cooper;S. Robson;J. Fishman
通讯作者：
J. Fishman
与非人灵长类动物的猪器官和造血细胞移植相关的凝血和血栓性疾病
影响因子：
6.2
作者：
L. Bühler;M. Basker;I. Alwayn;C. Goepfert;H. Kitamura;T. Kawai;S. Gojo;T. Kozłowski;F. Ierino;M. Awwad;D. Sachs;R. Sackstein;S. Robson;D. Cooper
通讯作者：
D. Cooper
影响因子：
82.9
作者：
Kuwaki, K;Tseng, YL;Cooper, DKC
通讯作者：
Cooper, DKC
通过混合嵌合的非清髓性诱导，在 α1,3-半乳糖基转移酶缺陷小鼠中实现了 T 细胞和 B 细胞对表达 Galα1,3gal 的心脏异种移植物的耐受1
DOI：
--
发表时间：
2001
期刊：
影响因子：
--
作者：
H. Ohdan;Yong;K. Swenson;H. Kitamura;M. Sykes
通讯作者：
M. Sykes