Physicochemical properties of newly developed bioactive glass cement and its effects on various cells.
Physicochemical properties of newly developed bioactive glass cement and its effects on various cells.
复制标题
新开发的生物活性玻璃水泥的理化性质及其对各种细胞的影响。
DOI：
10.1002/jbm.b.33209
复制
发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Kitamura C
中科院分区：
文献类型：
--
作者：
Washio A;Nakagawa A;Nishihara T;Maeda H;Kitamura C
用于牙科治疗的生物材料有望具有良好的特性，如生物相容性和诱导牙髓和根尖周组织形成的能力，以及密封以阻挡外部刺激。生物活性玻璃在骨工程领域的应用较多，但在牙科领域的应用较少。本研究研制了生物活性牙科治疗用玻璃胶粘剂，分析了其理化性质及其对细胞反应的影响。为了弄清水泥的物理化学性质，进行了场发射扫描电子显微镜、X射线衍射和pH测量。研究人员还检测了骨水泥对成牙细胞样细胞（KN‐3细胞）、成骨细胞（MC3T3‐E1细胞）、人牙周韧带干细胞/祖细胞和神经分化细胞（PC‐12细胞）的附着、形态和活力。硬化水泥表面形成类似羟基磷灰石的沉淀，pH值从pH10变化到pH9，然后在模拟体液中稳定下来。水泥对这些细胞没有细胞毒性作用，特别是对PC‐12细胞的过程伸长没有诱导作用。我们的研究结果表明，新开发的生物活性玻璃胶粘剂具有作为生物活性胶粘剂应用于牙科手术的能力。©2014 Wiley期刊公司[J]中国生物医学工程学报，2016,31(3):373 - 378。
Biomaterials used in dental treatments are expected to have favorable properties such as biocompatibility and an ability to induce tissue formation in dental pulp and periapical tissue, as well as sealing to block external stimuli. Bioactive glasses have been applied in bone engineering, but rarely applied in the field of dentistry. In the present study, bioactive glass cement for dental treatment was developed, and then its physicochemical properties and effects on cell responses were analyzed. To clarify the physicochemical attributes of the cement, field emission scanning electron microscopy, X‐ray diffraction, and pH measurement were carried out. Cell attachment, morphology, and viability to the cement were also examined to clarify the effects of the cement on odontoblast‐like cells (KN‐3 cells), osteoblastic cells (MC3T3‐E1 cells), human periodontal ligament stem/progenitor cells and neuro‐differentiative cells (PC‐12 cells). Hydroxyapatite‐like precipitation was formed on the surface of the hardened cement and the pH level changed from pH10 to pH9, then stabilized in simulate body fluid. The cement had no cytotxic effects on these cells, and particulary induced process elongation of PC‐12 cells. Our results suggest that the newly developed bioactive glass cement have capability of the application in dental procedures as bioactive cement. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 103B: 373–380, 2015.
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DOI：
10.1016/j.tripleo.2008.07.018
发表时间：
2008-12-01
期刊：
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY
影响因子：
--
作者：
Bramante, Clovis Monteiro;Cardoso Oliveira Demarchi, Ana Claudia;Hungaro Duarte, Marco Antonio
通讯作者：
Hungaro Duarte, Marco Antonio
评估磷酸促进的生物玻璃-牙本质相互作用层的耐久性
DOI：
--
发表时间：
2009
期刊：
影响因子：
--
作者：
A.S.Bakry;K.Matin;Y.Tanaka;M.Otsuki;H.Takahashi;K.Yamashita;J.Tagami
通讯作者：
J.Tagami
DOI：
10.1016/j.tripleo.2006.09.007
发表时间：
2007-03-01
期刊：
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY
影响因子：
--
作者：
Al-Daafas, Abdullah;Al-Nazhan, Saad
通讯作者：
Al-Nazhan, Saad
根穿孔修复材料的细胞毒性。
影响因子：
4.2
作者：
H. Makkawy;S. Koka;M. T. Lavin;N. Ewoldsen
通讯作者：
N. Ewoldsen
影响因子：
9.7
作者：
Zhao, Desheng;Moritz, Niko;Aro, Hannu T.
通讯作者：
Aro, Hannu T.