The impact of steroids given with macrolide therapy on experimental Mycoplasma pneumoniae respiratory infection.
The impact of steroids given with macrolide therapy on experimental Mycoplasma pneumoniae respiratory infection.
复制标题
DOI：
10.1086/591915
复制
发表时间：
2008-10-15
影响因子：
6.4
通讯作者：
Hardy, R. D.
中科院分区：
文献类型：
--
作者：
Tagliabue, C.;Salvatore, C. M.;Techasaensiri, C.;Mejias, A.;Torres, J. P.;Katz, K.;Gomez, A. M.;Esposito, S.;Principi, N.;Hardy, R. D.
对于重症肺炎支原体肺炎，除了抗菌药物治疗外，还提倡全身使用类固醇。我们评估了克拉霉素、地塞米松或联合治疗对M的疗效。肺炎呼吸道感染。感染M.每天用克拉霉素、地塞米松、组合的克拉霉素/地塞米松或安慰剂治疗肺炎的小鼠;在基线和治疗1、3和6天后评价小鼠。结果变量包括M。肺炎菌培养;肺组织病理学评分（HPS）;支气管肺泡灌洗细胞因子、趋化因子和生长因子浓度。克拉霉素单药治疗导致M降低最大。肺炎浓度。治疗3天后，与安慰剂、克拉霉素和地塞米松单药治疗相比，联合治疗显著降低了肺HPS;而治疗6天后，与安慰剂相比，克拉霉素单药治疗和联合治疗显著降低了肺HPS。与地塞米松单独给药和/或安慰剂相比，克拉霉素单独给药和/或联合给药小鼠的IL-12 p40、RANTES、MCP-1和KC显著降低;联合给药导致IL-12 p40和RANTES的降低程度显著大于克拉霉素单独给药。而克拉霉素单药治疗对降低M浓度的效果最大。对于肺炎，联合治疗对降低细胞因子和趋化因子以及肺组织学炎症具有最大的效果。
Systemic steroids have been advocated in addition to antimicrobial therapy for severe Mycoplasma pneumoniae pneumonia. We evaluated the efficacy of clarithromycin, dexamethasone, or combination therapy for M. pneumoniae respiratory infection. Mice infected with M. pneumoniae were treated with clarithromycin, dexamethasone, combined clarithromycin/dexamethasone, or placebo daily; mice were evaluated at baseline and after 1, 3, and 6 days of therapy. Outcome variables included M. pneumoniae culture; lung histopathologic score (HPS); bronchoalveolar lavage cytokine, chemokine and growth factor concentrations. Clarithromycin monotherapy resulted in the greatest reductions in M. pneumoniae concentrations. After 3 days of treatment, combination therapy significantly reduced lung HPS compared with placebo, clarithromycin, and dexamethasone alone; while after 6 days of therapy, clarithromycin alone and combination therapy significantly reduced lung HPS compared with placebo. IL-12 p40, RANTES, MCP-1, and KC were significantly lower in mice treated with clarithromycin alone and/or combination therapy compared with dexamethasone alone and/or placebo; combination therapy resulted in a significantly greater reduction than clarithromycin alone for IL-12 p40 and RANTES. While monotherapy with clarithromycin had the greatest effect on reducing concentrations of M. pneumoniae, combination therapy had the greatest effect on decreasing cytokines and chemokines, as well as pulmonary histologic inflammation.
登录
查看更多内容
DOI：
10.1165/rcmb.2002-0291oc
发表时间：
2003-09-01
影响因子：
6.4
作者：
Dakhama, A;Kraft, M;Gelfand, EW
通讯作者：
Gelfand, EW
DOI：
10.1164/ajrccm.156.3.9606031
发表时间：
1997-09-01
影响因子：
24.7
作者：
Hamelmann, E;Schwarze, J;Gelfand, EW
通讯作者：
Gelfand, EW
DOI：
10.1016/j.ijantimicag.2006.04.008
发表时间：
2006-09-01
影响因子：
10.8
作者：
Fonseca-Aten, Monica;Rios, Ana Maria;Hardy, R. Doug
通讯作者：
Hardy, R. Doug
DOI：
10.1001/jama.1961.03040150034009
发表时间：
1961-01-01
影响因子：
120.7
作者：
KINGSTON, JR;MUFSON, MA;FOX, HH
通讯作者：
FOX, HH
影响因子：
3.1
作者：
Cartner, SC;Lindsey, JR;Simecka, JW
通讯作者：
Simecka, JW