ABO blood group and breast cancer incidence and survival.
ABO blood group and breast cancer incidence and survival.
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DOI：
10.1002/ijc.26220
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发表时间：
2012-05-01
影响因子：
6.4
通讯作者：
Wolpin, Brian M.
中科院分区：
文献类型：
--
作者：
Gates, Margaret A.;Xu, Mousheng;Chen, Wendy Y.;Kraft, Peter;Hankinson, Susan E.;Wolpin, Brian M.
ABO血型与几种恶性肿瘤的风险和生存有关；然而，与乳腺癌相关的数据并不一致。我们的研究人群包括自我报告血清学血型和/或ABO基因型的护士健康研究参与者。使用Cox比例风险回归，我们检查了67,697名女性（包括3,107例）血清学血型与乳腺癌发病率之间的关系。此外，我们在1138例浸润性乳腺癌病例和1090例匹配对照的巢式病例对照研究中检测了ABO基因型与ABO基因型的关系。最后，我们评估了2036名乳腺癌患者血清学血型与生存率之间的关系。血清学血型或ABO基因型与乳腺癌、浸润性乳腺癌或乳腺癌亚型的风险之间没有明显的关联。O型血的女性相比,年龄调整发病率比血清学的血型和总乳腺癌类型为1.06 (95% CI, 0.98 - -1.15), 1.06(95%可信区间,0.93 - -1.22)AB,和1.08 (95% CI, 0.96 - -1.20) B基因分析、浸润性乳腺癌的优势比为1.05 (95% CI, 0.87 - -1.27) / O, 1.21(95%可信区间,0.86 - -1.69)/ A,为0.84 (95% CI, 0.56 - -1.26) A / B, B为0.84 (95% CI, 0.63 - -1.13) / O,和1.17 (95% CI, 0.35 - -3.86) B / B,而O / O。血型与总体或乳腺癌特异性死亡率之间没有明显的联系。我们的研究结果表明ABO血型与乳腺癌风险或生存率之间没有关联。
ABO blood type has been associated with risk and survival for several malignancies; however, data for an association with breast cancer are inconsistent. Our study population consisted of Nurses’ Health Study participants with self-reported serologic blood type and/or ABO genotype. Using Cox proportional hazards regression, we examined the association between serologic blood type and incident breast cancer among 67,697 women, including 3,107 cases. In addition, we examined the association with ABO genotype in a nested case-control study of 1,138 invasive breast cancer cases and 1,090 matched controls. Finally, we evaluated the association between serologic blood type and survival among 2,036 participants with breast cancer. No clear association was seen between serologic blood type or ABO genotype and risk of total breast cancer, invasive breast cancer, or breast cancer subtypes. Compared to women with blood type O, the age-adjusted incidence rate ratios for serologic blood type and total breast cancer were 1.06 (95% CI, 0.98–1.15) for type A, 1.06 (95% CI, 0.93–1.22) for AB, and 1.08 (95% CI, 0.96–1.20) for B. In genetic analyses, odds ratios for invasive breast cancer were 1.05 (95% CI, 0.87–1.27) for A/O, 1.21 (95% CI, 0.86–1.69) for A/A, 0.84 (95% CI, 0.56–1.26) for A/B, 0.84 (95% CI, 0.63–1.13) for B/O, and 1.17 (95% CI, 0.35–3.86) for B/B, compared to O/O. No significant association was noted between blood type and overall or breast cancer-specific mortality. Our results suggest no association between ABO blood group and breast cancer risk or survival.
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影响因子：
4.5
作者：
Melzer D;Perry JR;Hernandez D;Corsi AM;Stevens K;Rafferty I;Lauretani F;Murray A;Gibbs JR;Paolisso G;Rafiq S;Simon-Sanchez J;Lango H;Scholz S;Weedon MN;Arepalli S;Rice N;Washecka N;Hurst A;Britton A;Henley W;van de Leemput J;Li R;Newman AB;Tranah G;Harris T;Panicker V;Dayan C;Bennett A;McCarthy MI;Ruokonen A;Jarvelin MR;Guralnik J;Bandinelli S;Frayling TM;Singleton A;Ferrucci L
通讯作者：
Ferrucci L
影响因子：
6.4
作者：
Ben, Qiwen;Wang, Kaixuan;Li, Zhaoshen
通讯作者：
Li, Zhaoshen
影响因子：
2.9
作者：
Garratty, G;Glynn, SA;McEntire, R
通讯作者：
McEntire, R
影响因子：
2.1
作者：
Kraft, P;Cox, DG;De Vivo, I
通讯作者：
De Vivo, I
影响因子：
8.4
作者：
Iodice, Simona;Maisonneuve, Patrick;Lowenfels, Albert B.
通讯作者：
Lowenfels, Albert B.