Red-shifted optogenetics comes to the spotlight.
Red-shifted optogenetics comes to the spotlight.
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DOI：
10.1002/ctm2.807
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发表时间：
2022-04
影响因子：
10.6
通讯作者：
Zhou Y
中科院分区：
文献类型：
--
作者：
Wang T;Liu S;Huang Y;Zhou Y
Optogenetics has emerged as a powerful technique to precisely manipulate protein activity and cell signalling in space and time since its first introduction to the neuroscience field in 2005 1, 2. The clinical translation of optogenetics has gained momentum by the recent demonstration of a red-shifted microbial opsin ChrimsonR to partially restore the vision of a blind patient with a singledose adeno-associated virus (AAV) injection into the eyes. 3 Photosensory modules responding to red/far-red light offer an ideal solution for future wireless optogenetic therapies due to their deep tissue penetration capability and relatively low phototoxicity. The applications of these red/farred light-switchable optogenetic devices, in theory, can be expanded into clinical domains beyond ophthalmology to encompass neurology, psychiatry, endocrinology, and oncology.
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影响因子：
13.6
作者：
Wang X;Dong K;Kong D;Zhou Y;Yin J;Cai F;Wang M;Ye H
通讯作者：
Ye H
影响因子：
4.7
作者：
Huang Z;Li Z;Zhang X;Kang S;Dong R;Sun L;Fu X;Vaisar D;Watanabe K;Gu L
通讯作者：
Gu L
影响因子：
38.3
作者：
Nguyen NT;Huang K;Zeng H;Jing J;Wang R;Fang S;Chen J;Liu X;Huang Z;You MJ;Rao A;Huang Y;Han G;Zhou Y
通讯作者：
Zhou Y
DOI：
10.1038/nrn.2017.15
发表时间：
2017-03-17
期刊：
Nature reviews. Neuroscience
影响因子：
--
作者：
Kim CK;Adhikari A;Deisseroth K
通讯作者：
Deisseroth K
影响因子：
33.6
作者：
Tan P;He L;Huang Y;Zhou Y
通讯作者：
Zhou Y