Integration of optogenetics with complementary methodologies in systems neuroscience.
Integration of optogenetics with complementary methodologies in systems neuroscience.
复制标题
DOI：
10.1038/nrn.2017.15
复制
发表时间：
2017-03-17
期刊：
影响因子：
--
通讯作者：
Deisseroth K
中科院分区：
文献类型：
--
作者：
Kim CK;Adhikari A;Deisseroth K
Modern optogenetics can be tuned to evoke activity that corresponds to naturally occurring local or global activity in timing, magnitude or individual-cell patterning. This outcome has been facilitated not only by the development of core features of optogenetics over the past 10 years (microbial-opsin variants, opsin-targeting strategies and light-targeting devices) but also by the recent integration of optogenetics with complementary technologies, spanning electrophysiology, activity imaging and anatomical methods for structural and molecular analysis. This integrated approach now supports optogenetic identification of the native, necessary and sufficient causal underpinnings of physiology and behaviour on acute or chronic timescales and across cellular, circuit-level or brain-wide spatial scales.
登录
查看更多内容
神经肽Y（NPY）受体配体的治疗潜力。
影响因子：
11.1
作者：
Brothers, Shaun P.;Wahlestedt, Claes
通讯作者：
Wahlestedt, Claes
使用ChannelRhopopsin-2的细胞型特异性表达，对体内神经元的靶向光遗传学刺激和记录。
影响因子：
14.8
作者：
通讯作者：
--
神经元型特异性信号，用于腹侧对段区域的奖励和惩罚。
影响因子：
64.8
作者：
Cohen, Jeremiah Y.;Haesler, Sebastian;Vong, Linh;Lowell, Bradford B.;Uchida, Naoshige
通讯作者：
Uchida, Naoshige
影响因子：
64.8
作者：
Cui, Guohong;Jun, Sang Beom;Jin, Xin;Pham, Michael D.;Vogel, Steven S.;Lovinger, David M.;Costa, Rui M.
通讯作者：
Costa, Rui M.
影响因子：
25
作者：
Boyden, ES;Zhang, F;Deisseroth, K
通讯作者：
Deisseroth, K