White matter microstructure shows sex differences in late childhood: Evidence from 6797 children.
White matter microstructure shows sex differences in late childhood: Evidence from 6797 children.
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DOI：
10.1002/hbm.26079
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发表时间：
2023-02-01
影响因子：
4.8
通讯作者：
中科院分区：
文献类型：
--
作者：
使用传统和先进的扩散加权磁共振成像方法，已在成人大脑中有力地证明了白质微结构的性别差异。然而，人们对成年前白质微观结构的性别差异仍知之甚少。之前的开发工作主要集中在传统的微观结构指标上，并产生了不同的结果。在这里，我们严格表征了青少年大脑认知发展研究中 6000 多名 9 至 10 岁儿童的白质微观结构的性别差异。使用传统模型（扩散张量成像 (DTI)）和先进模型（限制谱成像 (RSI)）对微观结构进行量化。 DTI 指标包括分数各向异性 (FA) 以及平均、轴向和径向扩散率（MD、AD、RD）。 RSI 指标包括标准化各向同性、定向和总细胞内扩散 (N0、ND、NT)。我们发现大脑中每个白质区域的 DTI 或 RSI 微观结构指标存在显着且可复制的性别差异。 FA 中的性别差异具有地区特异性。在白质区域，男孩平均表现出比女孩更高的 MD、AD 和 RD。平均而言，与男孩相比，女孩的 N0、ND 和 NT 有所增加，这表明女孩的细胞和神经突密度更高。总之，这些可靠且可复制的发现为理解健康和疾病方面的性别差异提供了重要基础。我们使用传统（扩散张量成像 [DTI]）和先进（限制谱成像 [RSI]）扩散加权 MRI 模型，对青少年大脑认知发展研究中 6000 多名 9 至 10 岁儿童的白质微结构发育性别差异进行了严格表征。在整个大脑检查的每个白质区域中，都观察到 DTI 或 RSI 微观结构指标的显着、可复制和稳健的性别差异。这些可靠且可复制的发现为理解健康和疾病方面的性别差异提供了重要基础。
Sex differences in white matter microstructure have been robustly demonstrated in the adult brain using both conventional and advanced diffusion‐weighted magnetic resonance imaging approaches. However, sex differences in white matter microstructure prior to adulthood remain poorly understood; previous developmental work focused on conventional microstructure metrics and yielded mixed results. Here, we rigorously characterized sex differences in white matter microstructure among over 6000 children from the Adolescent Brain Cognitive Development study who were between 9 and 10 years old. Microstructure was quantified using both the conventional model—diffusion tensor imaging (DTI)—and an advanced model, restriction spectrum imaging (RSI). DTI metrics included fractional anisotropy (FA) and mean, axial, and radial diffusivity (MD, AD, RD). RSI metrics included normalized isotropic, directional, and total intracellular diffusion (N0, ND, NT). We found significant and replicable sex differences in DTI or RSI microstructure metrics in every white matter region examined across the brain. Sex differences in FA were regionally specific. Across white matter regions, boys exhibited greater MD, AD, and RD than girls, on average. Girls displayed increased N0, ND, and NT compared to boys, on average, suggesting greater cell and neurite density in girls. Together, these robust and replicable findings provide an important foundation for understanding sex differences in health and disease. We rigorously characterized developmental sex differences in white matter microstructure using both conventional (diffusion tensor imaging [DTI]) and advanced (restriction spectrum imaging [RSI]) diffusion‐weighted MRI models among over 6000 children from the Adolescent Brain Cognitive Development study who were between 9 and 10 years old. Significant, replicable, and robust sex differences in DTI or RSI microstructure metrics were observed in every white matter region examined across the brain. These robust and replicable findings provide an important foundation for understanding sex differences in health and disease.
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影响因子：
4.8
作者：
Bohon C;Welch H
通讯作者：
Welch H
影响因子：
2.9
作者：
Buyanova IS;Arsalidou M
通讯作者：
Arsalidou M
影响因子：
5.7
作者：
Fick, Rutger H. J.;Wassermann, Demian;Deriche, Rachid
通讯作者：
Deriche, Rachid
DOI：
10.1006/jmrb.1994.1037
发表时间：
1994-03-01
期刊：
JOURNAL OF MAGNETIC RESONANCE SERIES B
影响因子：
--
作者：
BASSER, PJ;MATTIELLO, J;LEBIHAN, D
通讯作者：
LEBIHAN, D
影响因子：
5.7
作者：
Gustayson, Daniel E.;Hatton, Sean N.;Kremer, William S.
通讯作者：
Kremer, William S.