The role of the lateral habenula in punishment.
The role of the lateral habenula in punishment.
复制标题
外侧Habenula在惩罚中的作用。
DOI：
10.1371/journal.pone.0111699
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
McNally GP
中科院分区：
文献类型：
--
作者：
Jean-Richard Dit Bressel P;McNally GP
外侧缰核（LHb）是一个小的上丘脑结构，通过反束投射到中脑。已知LHb调节中脑多巴胺（DA）神经元，包括通过GABA能头内侧被盖核（RMTg）的多巴胺能兴奋来抑制腹侧被盖区（VTA）神经元。各种证据表明LHb和LHb-RMTg通路的活性与惩罚学习相关，并且足以支持惩罚学习。然而，目前还不清楚LHb是否是惩罚所必需的。在这里，我们使用了一个受试者内的惩罚任务，以评估的作用，LHb的收购和表达的惩罚，以及在厌恶的选择。按下两个单独呈现的杠杆以获得颗粒奖励的大鼠迅速抑制了对一个杠杆的反应，如果它也引起了脚震传递（惩罚杠杆），但继续按下第二个杠杆不会引起脚震（未惩罚杠杆）。注入AMPA受体拮抗剂（NBQX）到LHb没有影响收购或表达这种惩罚，或厌恶的选择，但增加运动。输注钠通道阻滞剂布比卡因同样对惩罚的表达没有影响。然而，输注钙通道阻滞剂米贝拉地尔确实通过显著降低大鼠对惩罚性杠杆的反应的潜伏期和显著增加未惩罚性按压来影响惩罚性表达。总之，这些发现表明，LHb在惩罚中发挥的作用有限，只影响反应的潜伏期。这种作用与钙通道通透性有关，而与AMPA受体或钠通道通透性无关。
The lateral habenula (LHb) is a small epithalamic structure that projects via the fasciculus retroflexus to the midbrain. The LHb is known to modulate midbrain dopamine (DA) neurons, including inhibition of ventral tegmental area (VTA) neurons via glutamatergic excitation of the GABAergic rostromedial tegmental nucleus (RMTg). A variety of lines of evidence show activity in LHb and the LHb-RMTg pathway is correlated with, and is sufficient to support, punishment learning. However, it is not immediately clear whether LHb is necessary for punishment. Here we used a within-subjects punishment task to assess the role of LHb in the acquisition and expression of punishment as well as in aversive choice. Rats that pressed two individually presented levers for pellet rewards rapidly suppressed responding to one lever if it also caused footshock deliveries (punished lever) but continued pressing a second lever that did not cause footshock (unpunished lever). Infusions of an AMPA receptor antagonist (NBQX) into LHb had no effect on the acquisition or expression of this punishment, or on aversive choice, but did increase locomotion. Infusion of the sodium channel blocker bupivacaine likewise had no effect on expression of punishment. However, infusion of the calcium channel blocker mibefradil did affect expression of punishment by significantly decreasing the latency with which rats responded on the punished lever and significantly increasing unpunished lever-pressing. Taken together, these findings indicate that the LHb plays a limited role in punishment, influencing only latency to respond. This role is linked to calcium channel permeability and not AMPA receptor or sodium channel permeability.
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