Thyroid function abnormalities and cognitive impairment in elderly people: results of the Invecchiare in Chianti study.
Thyroid function abnormalities and cognitive impairment in elderly people: results of the Invecchiare in Chianti study.
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DOI：
10.1111/j.1532-5415.2008.02080.x
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发表时间：
2009-01
影响因子：
6.3
通讯作者：
Ferrucci, Luigi
中科院分区：
文献类型：
--
作者：
Ceresini, Graziano;Lauretani, Fulvio;Maggio, Marcello;Ceda, Gian Paolo;Morganti, Simonetta;Usberti, Elisa;Chezzi, Carlo;Valcavi, Rita;Bandinelli, Stefania;Guralnik, Jack M.;Cappola, Anne R.;Valenti, Giorgio;Ferrucci, Luigi
目的：了解老年人甲状腺功能检测异常情况，探讨甲状腺功能障碍与认知功能的关系。通过测定血浆促甲状腺激素(TSH)、游离甲状腺素(FT4)和游离三碘甲状腺原氨酸(FT3)的浓度，对1171名年龄在23-102岁的社区男性和女性的甲状腺功能进行了评估。采用简易精神状态检查(MMSE)评定认知功能。评估了不同年龄组(65岁与≥65岁)显性和亚临床甲状腺功能障碍的患病率。在甲状腺功能正常的参与者中检查了TSH、FT4和FT3的年龄趋势。调整混杂因素，评估甲状腺功能障碍与MMSE评分的横断面关联性。亚临床甲状腺功能减退症和亚临床甲状腺功能亢进症在老年人中比在年轻参与者中更常见(亚临床甲状腺功能减退症在年轻参与者中分别为0.4%比3.5%，在年轻参与者中分别为1.9%与7.8%，P<；.002)。在甲状腺功能正常的参与者中，TSH和FT3随着年龄的增长而下降，而FT4则上升。老年亚临床甲亢患者的MMSE评分低于正常甲状腺患者(22.61±6.88比24.72±4.52，P<；.03)。在调整后的分析中，患有亚临床甲亢的参与者明显更有可能出现认知功能障碍(HR：2.26，P=.003)。在甲状腺功能正常的个体中，FT3、FT4和TSH会发生与年龄相关的微妙变化。亚临床甲状腺功能亢进症是意大利老年人中最常见的甲状腺功能障碍，与认知障碍有关。
To investigate thyroid function testing abnormalities in older persons and to explore the relationship between thyroid dysfunction and cognition. Cross-sectional study Community-based 1171 men and women aged 23-102 yrs Thyroid function was evaluated by measuring plasma concentrations of thyrotropin (TSH), free thyroxine (FT4), and free triiodothyronine (FT3). Cognition was evaluated by the Mini Mental State Examination (MMSE). Prevalence of overt and subclinical thyroid dysfunction was evaluated in different age groups (<65 versus ≥65 years). Age trends in TSH, FT4, and FT3 were examined in euthyroid participants. The cross-sectional association of thyroid dysfunction with MMSE score was evaluated adjusting for confounders. Both subclinical hypothyroidism and subclinical hyperthyroidism were more prevalent in older than in younger participants (Subclinical hypothyroidism, 0.4 % vs 3.5 % in younger vs older participants, respectively, P<.03 Subclinical hyperthyroidism, 1.9 % vs 7.8 % in younger vs older participants, respectively, P<.002). In euthyroid participants TSH and FT3 declined with age while FT4 increased. Old participants with subclinical hyperthyroidism had a lower MMSE score than euthyroid subjects (22.61 ± 6.88 vs 24.72 ± 4.52, P<.03). In adjusted analyses, participants with subclinical hyperthyroidism were significantly more likely to have cognitive dysfunction (HR: 2.26, P= .003). Subtle age-related changes in FT3, FT4 and TSH occur in individuals who remain euthyroid. Subclinical hyperthyroidism is the most prevalent thyroid dysfunction in Italian older persons and is associated with cognitive impairment.
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影响因子：
5.8
作者：
Aghini-Lombardi, F;Antonangeli, L;Pinchera, A
通讯作者：
Pinchera, A
影响因子：
3.2
作者：
EWINS, DL;ROSSOR, MN;MCGREGOR, AM
通讯作者：
MCGREGOR, AM
DOI：
10.1111/j.1532-5415.2000.tb03873.x
发表时间：
2000-12-01
影响因子：
6.3
作者：
Ferrucci, L;Bandinelli, S;Guralnik, JM
通讯作者：
Guralnik, JM
影响因子：
39.2
作者：
Roberts, Lesley M.;Pattison, Helen;Parle, James V.
通讯作者：
Parle, James V.
影响因子：
120.7
作者：
Cappola, AR;Fried, LP;Ladenson, PW
通讯作者：
Ladenson, PW