Maternal iron deficiency and the risk of schizophrenia in offspring.
Maternal iron deficiency and the risk of schizophrenia in offspring.
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DOI：
10.1001/archpsyc.65.10.1136
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发表时间：
2008-10
影响因子：
--
通讯作者：
Brown, Alan S.
中科院分区：
文献类型：
--
作者：
Insel, Beverly J.;Schaefer, Catherine A.;McKeague, Ian W.;Susser, Ezra S.;Brown, Alan S.
铁对大脑发育和功能至关重要。新出现的证据表明，生命早期缺铁会导致婴儿和儿童长期的神经和行为缺陷。采用生命历程的观点，我们检查了早期缺铁对成年后精神分裂症风险的影响。通过妊娠期母体血红蛋白浓度评估母体缺铁是否会增加后代对精神分裂症谱系障碍（SSDs）的易感性。数据来自1959年至1967年出生的人群队列，并从1981年至1997年随访SSD的发展情况。在6872名可获得母体血红蛋白浓度的后代中，57名（0.8%）有ssd， 6815名（99.2%）没有ssd。前瞻性分析，母体血红蛋白浓度的平均值是主要暴露。血红蛋白浓度作为连续变量和分类变量进行分析。与平均血红蛋白浓度为12.0 g/dL或更高的孕妇相比，平均血红蛋白浓度为10.0 g/dL或更低与ssd发生率增加近4倍相关（调整后的比率比为3.73；95%可信区间为1.41-9.81；P= 0.008），经母亲教育程度和种族调整后。母体平均血红蛋白浓度每增加1 g/dL， ssd发生率降低27%（95%置信区间，0.55-0.96；P= 0.02）。研究结果表明，母亲缺铁可能是后代患ssd的一个危险因素。鉴于这一假设提供了降低固态硬盘风险的可能性，有必要对独立样本进行进一步调查。
Iron is essential for brain development and functioning. Emerging evidence suggests that iron deficiency in early life leads to long-lasting neural and behavioral deficits in infants and children. Adopting a life course perspective, we examined the effects of early iron deficiency on the risk of schizophrenia in adulthood. To determine whether maternal iron deficiency, assessed by maternal hemoglobin concentration during pregnancy, increases the susceptibility to schizophrenia spectrum disorders (SSDs) among offspring. Data were drawn from a population-based cohort born from 1959 through 1967 and followed up for development of SSD from 1981 through 1997. Of 6872 offspring for whom maternal hemoglobin concentration was available, 57 had SSDs (0.8%) and 6815 did not (99.2%). Prospectively assayed, the mean value of maternal hemoglobin concentration was the primary exposure. Hemoglobin concentration was analyzed as a continuous and a categorical variable. A mean maternal hemoglobin concentration of 10.0 g/dL or less was associated with a nearly 4-fold statistically significant increased rate of SSDs (adjusted rate ratio, 3.73; 95% confidence interval, 1.41–9.81; P=.008) compared with a mean maternal hemoglobin concentration of 12.0 g/dL or higher, adjusting for maternal education and ethnicity. For every 1-g/dL increase in mean maternal hemoglobin concentration, a 27% decrease in the rate of SSDs was observed (95% confidence interval, 0.55–0.96; P=.02). The findings suggest that maternal iron deficiency may be a risk factor for SSDs among offspring. Given that this hypothesis offers the potential for reducing the risk for SSDs, further investigation in independent samples is warranted.
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