Burden of pneumonia and meningitis caused by Streptococcus pneumoniae in China among children under 5 years of age: a systematic literature review.
Burden of pneumonia and meningitis caused by Streptococcus pneumoniae in China among children under 5 years of age: a systematic literature review.
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DOI：
10.1371/journal.pone.0027333
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Wang XY
中科院分区：
文献类型：
--
作者：
Chen Y;Deng W;Wang SM;Mo QM;Jia H;Wang Q;Li SG;Li X;Yao BD;Liu CJ;Zhan YQ;Ji C;Lopez AL;Wang XY
为了了解中国1 - 59月龄儿童肺炎链球菌疾病的负担和流行病学，我们采用标准化算法对1980 - 2008年发表的文献进行了回顾。由于缺乏基于人群的肺炎球菌病（PD）监测，我们确定了全因肺炎、菌血症和脑膜炎负荷，这些综合征最常与S。pneumoniae，并应用S.从确定这三种综合征病因的研究中收集肺炎链球菌，以计算PD负荷。由于微生物学上的困难，在确定S。由于肺炎引起的肺炎可能低估了肺炎负担，我们还使用了从疫苗效力试验中获得的比例。1980年至2008年期间，1个月至59个月的儿童每年每10万人中有12 815例全因肺炎病例，每年每10万人中有526人死亡。脑膜炎病例为14例/100 000/年。我们估计，截至2000年，肺炎球菌肺炎和脑膜炎病例分别为260，768例（113，000 - 582，382）和902例（114- 4，463），肺炎球菌肺炎和脑膜炎死亡人数分别为10，703例（4，638 - 23，904）和75例（9-370）。当使用疗效试验的参数时，肺炎球菌肺炎病例和死亡人数分别为695，382（173，845 - 1，216，918）和28，542（7，136 - 49，949）。血清型19 F、19 A和14是从肺炎/脑膜炎患者获得的最常见的血清型。目前可用的疫苗预计将覆盖79.5%至88.4%的流行血清型。肺炎球菌对抗生素的耐药性较高，应考虑将肺炎球菌疫苗纳入常规免疫规划。基于人口的研究是必要的。
To understand the burden and epidemiology of Streptococcus pneumoniae disease among children between 1 and 59 months of age in China, we conducted a review of literature published between 1980 and 2008 applying standardized algorithms. Because of the absence of population-based surveillance for pneumococcal disease (PD), we identified all-cause pneumonia, bacteremia and meningitis burden, syndromes most commonly associated with S. pneumoniae, and applied the proportion of disease attributable to S. pneumoniae from studies that determined the etiology of these three syndromes to calculate PD burden. Because of the microbiologic difficulties in identifying S. pneumoniae–attributable pneumonia which likely underestimates the pneumonia burden, we also used the proportion obtained from vaccine efficacy trials. Between 1980 and 2008, there were 12,815 cases/100,000/year of all-cause pneumonia among children between 1 month and 59 months, with 526 deaths/100,000 annually. There were 14 meningitis cases/100,000/year. We estimate that as of 2000, there were 260,768 (113,000 to 582,382) and 902 (114–4,463) cases of pneumococcal pneumonia and meningitis, respectively with 10,703 (4,638–23,904) and 75 (9–370) pneumococcal pneumonia and meningitis deaths, respectively. Pneumococcal pneumonia cases and deaths were more than two-fold higher, 695,382 (173,845–1,216,918) and 28,542 (7,136–49,949), respectively, when parameters from efficacy trials were used. Serotypes 19F, 19A and 14 were the most common serotypes obtained from pneumonia/meningitis patients. Currently available vaccines are expected to cover 79.5% to 88.4% of the prevalent serotypes. With high antibiotic resistance, introducing pneumococcal vaccines to the routine immunization program should be considered in China. Population-based studies are warranted.
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影响因子：
11.8
作者：
Levine, OS;Liu, G;Yang, YH
通讯作者：
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影响因子：
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作者：
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DOI：
10.1016/0197-2456(86)90046-2
发表时间：
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期刊：
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作者：
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通讯作者：
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作者：
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