Olfactory interference during inhibitory backward pairing in honey bees.
Olfactory interference during inhibitory backward pairing in honey bees.
复制标题
蜜蜂抑制后向后配对期间的嗅觉干扰。
DOI：
10.1371/journal.pone.0003513
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发表时间：
2008
期刊：
影响因子：
3.7
通讯作者：
Smith BH
中科院分区：
文献类型：
--
作者：
Dacher M;Smith BH
受约束的工蜂是研究嗅觉可塑性的行为和神经基础的有价值的模型。长鼻延伸反应（PER；长鼻是蜜蜂的口器）是为了响应蔗糖刺激而释放的。如果蔗糖刺激之前出现一次或几次气味（前向配对），蜜蜂就会形成这种关联的记忆，并且随后仅出现气味就足以引发 PER。然而，两种刺激（蔗糖，然后是气味）之间的后向配对尚未在蜜蜂中进行过很大程度的研究，尽管脊椎动物文献表明它会引发某种形式的抑制可塑性。如果饥饿的蜜蜂喂食蔗糖，它们会释放出持久的PER；然而，如果在蔗糖后 15 秒（但不是 7 或 30 秒）出现气味（向后配对），则可以中断该 PER。我们将这种以前未报道的过程称为嗅觉干扰。接受这 15 秒反向配对的蜜蜂在随后的单次正向配对（兴奋性条件反射）试验后表现出性能下降。结果分析支持嗅觉干扰与反向配对诱导的抑制性学习/记忆之间的关系。将药物西咪替丁注射到后脑会损害嗅觉干扰。嗅觉干扰取决于气味和 PER 之间的关联，而不是气味和蔗糖之间的关联。此外，将某种气味与蔗糖配对可以导致该气味与 PER 相关联，或者导致该气味抑制 PER。嗅觉干扰可以帮助我们深入了解气味-PER 关联的兴奋性和抑制性记忆如何形成的过程。
Restrained worker honey bees are a valuable model for studying the behavioral and neural bases of olfactory plasticity. The proboscis extension response (PER; the proboscis is the mouthpart of honey bees) is released in response to sucrose stimulation. If sucrose stimulation is preceded one or a few times by an odor (forward pairing), the bee will form a memory for this association, and subsequent presentations of the odor alone are sufficient to elicit the PER. However, backward pairing between the two stimuli (sucrose, then odor) has not been studied to any great extent in bees, although the vertebrate literature indicates that it elicits a form of inhibitory plasticity. If hungry bees are fed with sucrose, they will release a long lasting PER; however, this PER can be interrupted if an odor is presented 15 seconds (but not 7 or 30 seconds) after the sucrose (backward pairing). We refer to this previously unreported process as olfactory interference. Bees receiving this 15 second backward pairing show reduced performance after a subsequent single forward pairing (excitatory conditioning) trial. Analysis of the results supported a relationship between olfactory interference and a form of backward pairing-induced inhibitory learning/memory. Injecting the drug cimetidine into the deutocerebrum impaired olfactory interference. Olfactory interference depends on the associative link between odor and PER, rather than between odor and sucrose. Furthermore, pairing an odor with sucrose can lead either to association of this odor to PER or to the inhibition of PER by this odor. Olfactory interference may provide insight into processes that gate how excitatory and inhibitory memories for odor-PER associations are formed.
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2
作者：
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发表时间：
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