Do Febrile Seizures Cause Mesial Temporal Sclerosis?
Do Febrile Seizures Cause Mesial Temporal Sclerosis?
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高热惊厥会导致内侧颞叶硬化吗？
DOI：
10.1046/j.1535-7597.2003.03403.x
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发表时间：
2003
影响因子：
3.6
通讯作者：
Theodore,WilliamH.
中科院分区：
文献类型：
--
作者：
Theodore,WilliamH.
目的：探讨高热惊厥是否导致内侧颞叶硬化症(MTS)。方法：对329例高热惊厥患者中24例首次高热惊厥持续发作，8例首次高热惊厥后无缘性惊厥，32例年龄、性别、利手相匹配的单纯性高热惊厥后无无缘性惊厥的对照组进行前瞻性随访。通过对杏仁核和海马结构的MR体积测量和内侧颞叶结构的定性分析，评价MTS的发生情况。结果：所有患者均未发生MTS。左右海马结构和杏仁核的平均总体积在三组中的任何一组之间都没有显著差异。定性分析显示内侧颞区无硬化性改变。持续发热性惊厥患者的平均左右海马区体积差低于对照组，但对结果无影响。结论：持续发热性惊厥后出现MTS是一种罕见的事件，证实了发热性惊厥的良好临床转归。
OBJECTIVE: To determine whether febrile seizures cause mesial temporal sclerosis (MTS), the occurrence of MTS was evaluated in an unselected series of patients with febrile seizures.METHODS: Twenty-four patients with a prolonged first febrile seizure, 8 with an unprovoked seizure after the first febrile seizure, and 32 age-, sex-, and handedness-matched control subjects with a single simple febrile seizure without later unprovoked seizures were selected from 329 febrile seizure patients followed up prospectively. The occurrence of MTS was evaluated after a mean follow-up time of 12.3 years by MR volumetry of amygdala and hippocampal formation and qualitative analysis of mesial temporal structures.RESULTS: None of the patients had MTS. The mean total volumes of the right and left hippocampal formations and amygdala did not differ significantly between any of the three groups. The qualitative analysis revealed no sclerotic changes in the mesial temporal area. The patients with a prolonged initial febrile seizure had a lower mean right-left volume difference in hippocampal formations than the control subjects, but this had no effect on the outcome.CONCLUSION: The occurrence of MTS following even prolonged febrile seizures is an uncommon event, confirming the good clinical outcome of febrile seizures.
影响因子：
11
作者：
Bower, SPC;Kilpatrick, CJ;Cook, MJ
通讯作者：
Cook, MJ
220 名儿童热性惊厥——12 年随访的神经系统后遗症
影响因子：
2.4
作者：
B. Macdonald;A. Johnson;Josemir W Sander;S. Shorvon
通讯作者：
S. Shorvon
影响因子：
2.2
作者：
Davies, KG;Hermann, BP;Wyler, AR
通讯作者：
Wyler, AR