Incidence of COVID-19 recurrence among large cohort of healthcare employees.
Incidence of COVID-19 recurrence among large cohort of healthcare employees.
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DOI：
10.1016/j.annepidem.2021.04.005
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发表时间：
2021-08
影响因子：
5.6
通讯作者：
Jon R
中科院分区：
文献类型：
--
作者：
Veronica F;Anne R;Christopher B;Kenneth C;Jon R
量化具有SARS-CoV-2 IgG抗体或既往COVID-19感染的临床和非临床医护人员的COVID-19复发率。这项前瞻性队列研究收集了2020年6月8日至7月10日期间SARS-CoV-2 IgG血清样本，结果为阳性或阴性，该样本来自一家大型中西部医疗保健系统雇用的16，233名成年参与者的便利样本。在IgG检测前后长达四个月的时间内，记录了代表COVID-19感染的聚合酶链反应检测阳性结果。913名（6.12%）受试者，包括45名（4.93%）IgG阳性受试者，在研究开始后经历了COVID-19感染，这表明IgG阳性受试者中COVID-19感染的风险增加了51%（IRR = 1.51）。根据记录的差异进行调整后的回归显示，不同IgG状态的COVID-19感染没有差异（OR=1.19; P = .3117），但在既往记录过COVID-19感染的参与者中，COVID-19复发的几率显着更大（OR=1.93; P < .0001）。SARS-CoV-2 IgG抗体和既往COVID-19感染似乎不能为医护人员提供有意义的COVID-19复发保护。复发将影响有关持续医疗资源利用的决策。这项研究可以为弱势群体接种疫苗提供参考。
To quantify COVID-19 recurrence among clinical and nonclinical healthcare employees with SARS-CoV-2 IgG antibodies or prior COVID-19 infection. This prospective, cohort study collected and resulted SARS-CoV-2 IgG serum samples as positive or negative from June 8 to July 10, 2020 from a convenience sample of 16,233 adult participants employed by a large Midwestern healthcare system. Documented positive polymerase chain reaction test results representing COVID-19 infections were recorded up to four months prior to and post-IgG testing. Nine hundred and thirteen (6.12%) participants, including 45 (4.93%) IgG positive participants, experienced COVID-19 infections after study initiation, representing a 51% increased risk of COVID-19 infection among IgG positive participants (IRR = 1.51). Regressions adjusted for documented disparities showed no difference in COVID-19 infection by IgG status (OR=1.19; P = .3117) but significantly greater odds in COVID-19 recurrence among participants with a prior documented COVID-19 infection (OR=1.93; P < .0001). SARS-CoV-2 IgG antibodies and prior COVID-19 infection do not appear to offer meaningful protection against COVID-19 recurrence in healthcare workers. Recurrence would impact decisions regarding ongoing healthcare resource utilization. This study can inform considerations for vaccine administration to vulnerable groups.
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影响因子：
9.4
作者：
Lieberman, Joshua A.;Pepper, Gregory;Greninger, Alexander L.
通讯作者：
Greninger, Alexander L.
DOI：
10.1056/nejmoa2034545
发表时间：
2021-02-11
期刊：
The New England journal of medicine
影响因子：
--
作者：
Lumley SF;O'Donnell D;Stoesser NE;Matthews PC;Howarth A;Hatch SB;Marsden BD;Cox S;James T;Warren F;Peck LJ;Ritter TG;de Toledo Z;Warren L;Axten D;Cornall RJ;Jones EY;Stuart DI;Screaton G;Ebner D;Hoosdally S;Chand M;Crook DW;O'Donnell AM;Conlon CP;Pouwels KB;Walker AS;Peto TEA;Hopkins S;Walker TM;Jeffery K;Eyre DW;Oxford University Hospitals Staff Testing Group
通讯作者：
Oxford University Hospitals Staff Testing Group
DOI：
10.1001/jama.2020.7869
发表时间：
2020-06-09
期刊：
JAMA
影响因子：
--
作者：
Kirkcaldy RD;King BA;Brooks JT
通讯作者：
Brooks JT
影响因子：
2.9
作者：
Hoang T
通讯作者：
Hoang T
DOI：
10.1007/978-1-4939-2438-7_1
发表时间：
2015
期刊：
Methods in molecular biology (Clifton, N.J.)
影响因子：
--
作者：
Fehr, Anthony R;Perlman, Stanley
通讯作者：
Perlman, Stanley