Bedside to bench: the outlook for psychedelic research.
Bedside to bench: the outlook for psychedelic research.
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DOI：
10.3389/fphar.2023.1240295
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发表时间：
2023
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
--
作者：
最近有一个在迷幻化合物的基础上的研究，证明其在治疗创伤后应激障碍，药物滥用障碍，和治疗难治性抑郁症的潜在治疗应用的兴趣死灰复燃。尽管在一些临床试验中观察到有希望的疗效，但这些化合物的全部生物学效应和作用机制尚未完全确立。事实上，迄今为止的大多数研究都集中在评估致幻剂的心理机制上，往往忽视了非心理作用模式。然而，重要的是要理解，致幻剂可以通过多方面的机制来介导其治疗效果，例如调节脑网络活动、神经元可塑性、神经内分泌功能、胶质细胞调节、表观遗传过程和肠-脑轴。这篇评论提供了一个框架，支持实施一个多方面的方法，将在硅片，在体外和体内建模，以帮助全面了解致幻剂的生理效应及其潜在的临床应用超出精神疾病的治疗。我们还提供了支持致幻剂治疗脑损伤的潜在效用的文献综述（例如，中风和创伤性脑损伤），神经变性疾病（例如，帕金森病和阿尔茨海默病），以及与精神障碍相关的肠-脑轴功能障碍（例如，广泛性焦虑症和重度抑郁症）。为了推动这一领域的发展，我们概述了有利的实验框架，以探索迷幻药的这些和其他新的应用。
There has recently been a resurgence of interest in psychedelic compounds based on studies demonstrating their potential therapeutic applications in treating post-traumatic stress disorder, substance abuse disorders, and treatment-resistant depression. Despite promising efficacy observed in some clinical trials, the full range of biological effects and mechanism(s) of action of these compounds have yet to be fully established. Indeed, most studies to date have focused on assessing the psychological mechanisms of psychedelics, often neglecting the non-psychological modes of action. However, it is important to understand that psychedelics may mediate their therapeutic effects through multi-faceted mechanisms, such as the modulation of brain network activity, neuronal plasticity, neuroendocrine function, glial cell regulation, epigenetic processes, and the gut-brain axis. This review provides a framework supporting the implementation of a multi-faceted approach, incorporating in silico, in vitro and in vivo modeling, to aid in the comprehensive understanding of the physiological effects of psychedelics and their potential for clinical application beyond the treatment of psychiatric disorders. We also provide an overview of the literature supporting the potential utility of psychedelics for the treatment of brain injury (e.g., stroke and traumatic brain injury), neurodegenerative diseases (e.g., Parkinson’s and Alzheimer’s diseases), and gut-brain axis dysfunction associated with psychiatric disorders (e.g., generalized anxiety disorder and major depressive disorder). To move the field forward, we outline advantageous experimental frameworks to explore these and other novel applications for psychedelics.
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影响因子：
64.8
作者：
Cameron LP;Tombari RJ;Lu J;Pell AJ;Hurley ZQ;Ehinger Y;Vargas MV;McCarroll MN;Taylor JC;Myers-Turnbull D;Liu T;Yaghoobi B;Laskowski LJ;Anderson EI;Zhang G;Viswanathan J;Brown BM;Tjia M;Dunlap LE;Rabow ZT;Fiehn O;Wulff H;McCorvy JD;Lein PJ;Kokel D;Ron D;Peters J;Zuo Y;Olson DE
通讯作者：
Olson DE
影响因子：
5.6
作者：
Borbély E;Varga V;Szögi T;Schuster I;Bozsó Z;Penke B;Fülöp L
通讯作者：
Fülöp L
影响因子：
4.7
作者：
Breit S;Kupferberg A;Rogler G;Hasler G
通讯作者：
Hasler G
影响因子：
2.8
作者：
Baggott, Matthew J.;Garrison, Kathleen J.;Mendelson, John E.
通讯作者：
Mendelson, John E.
影响因子：
56.9
作者：
BROWN, IR;LIEW, CC
通讯作者：
LIEW, CC