Vagus Nerve as Modulator of the Brain-Gut Axis in Psychiatric and Inflammatory Disorders.
Vagus Nerve as Modulator of the Brain-Gut Axis in Psychiatric and Inflammatory Disorders.
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DOI：
10.3389/fpsyt.2018.00044
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发表时间：
2018
影响因子：
4.7
通讯作者：
Hasler G
中科院分区：
文献类型：
--
作者：
Breit S;Kupferberg A;Rogler G;Hasler G
迷走神经是副交感神经系统的主要组成部分，负责监督大量重要的身体功能，包括控制情绪，免疫反应，消化和心率。它建立了大脑和胃肠道之间的联系之一，并通过传入纤维将有关内脏器官状态的信息发送到大脑。在这篇综述文章中，我们讨论了迷走神经的各种功能，使其成为治疗精神病和胃肠道疾病的一个有吸引力的目标。有初步证据表明，迷走神经刺激是一个有前途的附加治疗难治性抑郁症，创伤后应激障碍，炎症性肠病。靶向迷走神经的治疗增加迷走神经张力并抑制细胞因子产生。两者都是恢复力的重要机制。肠道中迷走神经传入纤维的刺激会影响脑干中的单胺能脑系统，该系统在主要精神疾病（如情绪和焦虑症）中起着至关重要的作用。与此一致，有初步证据表明肠道细菌对情绪和焦虑有有益的影响，部分原因是影响迷走神经的活动。由于迷走神经张力与调节压力反应的能力相关，并且可以受到呼吸的影响，因此通过冥想和瑜伽增加迷走神经张力可能有助于恢复和缓解情绪和焦虑症状。
The vagus nerve represents the main component of the parasympathetic nervous system, which oversees a vast array of crucial bodily functions, including control of mood, immune response, digestion, and heart rate. It establishes one of the connections between the brain and the gastrointestinal tract and sends information about the state of the inner organs to the brain via afferent fibers. In this review article, we discuss various functions of the vagus nerve which make it an attractive target in treating psychiatric and gastrointestinal disorders. There is preliminary evidence that vagus nerve stimulation is a promising add-on treatment for treatment-refractory depression, posttraumatic stress disorder, and inflammatory bowel disease. Treatments that target the vagus nerve increase the vagal tone and inhibit cytokine production. Both are important mechanism of resiliency. The stimulation of vagal afferent fibers in the gut influences monoaminergic brain systems in the brain stem that play crucial roles in major psychiatric conditions, such as mood and anxiety disorders. In line, there is preliminary evidence for gut bacteria to have beneficial effect on mood and anxiety, partly by affecting the activity of the vagus nerve. Since, the vagal tone is correlated with capacity to regulate stress responses and can be influenced by breathing, its increase through meditation and yoga likely contribute to resilience and the mitigation of mood and anxiety symptoms.
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影响因子：
2.7
作者：
Byrne G;Rosenfeld G;Leung Y;Qian H;Raudzus J;Nunez C;Bressler B
通讯作者：
Bressler B
影响因子：
4
作者：
Alcock, Joe;Maley, Carlo C.;Aktipis, C. Athena
通讯作者：
Aktipis, C. Athena
影响因子：
2.7
作者：
Berlau, Daniel J.;McGaugh, James L.
通讯作者：
McGaugh, James L.
DOI：
10.2147/mder.s41017
发表时间：
2013
期刊：
Medical devices (Auckland, N.Z.)
影响因子：
--
作者：
Berry SM;Broglio K;Bunker M;Jayewardene A;Olin B;Rush AJ
通讯作者：
Rush AJ
影响因子：
64.5
作者：
Bellono NW;Bayrer JR;Leitch DB;Castro J;Zhang C;O'Donnell TA;Brierley SM;Ingraham HA;Julius D
通讯作者：
Julius D