Paramagnetic rim lesions are associated with pathogenic CSF profiles and worse clinical status in multiple sclerosis: A retrospective cross-sectional study.
Paramagnetic rim lesions are associated with pathogenic CSF profiles and worse clinical status in multiple sclerosis: A retrospective cross-sectional study.
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DOI：
10.1177/13524585221102921
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发表时间：
2022-11
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
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顺磁边缘已被观察到作为一个特征，一些MS病变的敏感性MRI和指示分区炎症。研究临床，MRI和鞘内（脑脊液，CSF）使用3T MRI在ms顺磁边缘病变（PRL）的相关性。所有患者均采用T2加权序列进行3T MRI，并进行敏感性后处理（SWAN方案，GE）。人工检查天鹅导出的滤波相位图和相应的T2-FLAIR图像以确定PRL。描述性统计、t检验和回归确定了人口统计学、临床、MRI和CSF与PRL的关联。纳入147例MS患者；其中79人有可用CSF。43%的人至少有1次PRL。PRL状态（存在/不存在）不因性别或EDSS而变化，但与年龄更年轻、病程更短、疾病严重程度更差、使用更有效的治疗、更差的灵活性以及年龄调整后的更低的脑容量和认知处理速度有关。此外，PRL状态与血脑屏障破坏有关，这是由病理升高的白蛋白商确定的。敏感性分析仍然支持这些发现。PRL是一种新兴的慢性神经炎症的无创生物标志物，已被证实与更严重的疾病有关，并初步显示与血脑屏障破坏有关。
Paramagnetic rims have been observed as a feature of some MS lesions on susceptibility-sensitive MRI and indicate compartmentalized inflammation. To investigate clinical, MRI, and intrathecal (cerebrospinal fluid, CSF) associations of paramagnetic rim lesions (PRL) using 3T MRI in MS. This is a retrospective, cross-sectional analysis. All patients underwent 3T MRI using a T2*-weighted sequence with susceptibility postprocessing (SWAN protocol, GE). SWAN-derived filtered phase maps and corresponding T2-FLAIR images were manually reviewed to determine PRL. Descriptive statistics, t-tests, and regression determined demographic, clinical, MRI, and CSF associations with PRL. 147 MS patients were included; 79 of whom had available CSF. Forty-three percent had at least 1 PRL. PRL status (presence/absence) did not vary by sex or EDSS but was associated with younger age, shorter disease duration, worse disease severity, higher-efficacy therapy use, and poorer dexterity, as well as lower age-adjusted brain volumes and cognitive processing speeds. PRL status was moreover associated with blood-brain-barrier disruption as determined by pathologically-elevated albumin quotient. Sensitivity analyses remained supportive of these findings. PRL, an emerging noninvasive biomarker of chronic neuroinflammation, are confirmed to be associated with greater disease severity and newly shown to be preliminarily associated with blood-brain-barrier disruption.
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影响因子：
3.7
作者：
Ng Kee Kwong KC;Mollison D;Meijboom R;York EN;Kampaite A;Thrippleton MJ;Chandran S;Waldman AD
通讯作者：
Waldman AD
DOI：
10.1056/nejmra1401483
发表时间：
2018-01-11
期刊：
The New England journal of medicine
影响因子：
--
作者：
Reich DS;Lucchinetti CF;Calabresi PA
通讯作者：
Calabresi PA
影响因子：
11.2
作者：
Maggi, Pietro;Sati, Pascal;Nair, Govind;Cortese, Irene C. M.;Jacobson, Steven;Smith, Bryan R.;Nath, Avindra;Ohayon, Joan;van Pesch, Vincent;Perrotta, Gaetano;Pot, Caroline;Theaudin, Marie;Martinelli, Vittorio;Scotti, Roberta;Wu, Tianxia;Du Pasquier, Renaud;Calabresi, Peter A.;Filippi, Massimo;Reich, Daniel S.;Absinta, Martina
通讯作者：
Absinta, Martina
影响因子：
14.5
作者：
Dal-Bianco, Assunta;Grabner, Guenther;Hametner, Simon
通讯作者：
Hametner, Simon
影响因子：
5.8
作者：
Manouchehrinia, Ali;Westerlind, Helga;Hillert, Jan
通讯作者：
Hillert, Jan