The prevalence of paramagnetic rim lesions in multiple sclerosis: A systematic review and meta-analysis.
The prevalence of paramagnetic rim lesions in multiple sclerosis: A systematic review and meta-analysis.
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DOI：
10.1371/journal.pone.0256845
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发表时间：
2021
期刊：
影响因子：
3.7
通讯作者：
Waldman AD
中科院分区：
文献类型：
--
作者：
Ng Kee Kwong KC;Mollison D;Meijboom R;York EN;Kampaite A;Thrippleton MJ;Chandran S;Waldman AD
最近几项研究的结果表明，使用基于磁共振成像的顺磁边缘病变可以代表多发性硬化症（MS）的潜在诊断和预后生物标志物。在此，我们对现有文献进行系统回顾和荟萃分析，以评估其在病变水平和患者水平的合并患病率。进行了数据库检索（PubMed和Embase）和手动检索，以识别允许计算边缘病变或慢性活动性病变的病变水平和/或患者水平患病率的研究。使用DerSimonian-Laird随机效应模型估计合并患病率。进行亚组分析和荟萃回归以探索异质性的可能来源。PROSPERO注册号：CRD 42020192282。29项研究（包括1230例患者）符合分析条件。荟萃分析估计病灶水平和患者水平边缘病变的合并患病率分别为9.8%（95% CI：6.6 - 14.2）和40.6%（95% CI：26.2 - 56.8）。慢性活动性病变的合并病变水平和患者水平患病率分别为12.0%（95% CI：9.0 - 15.8）和64.8%（95% CI：54.3 - 74.0）。在各项研究中观察到相当大的异质性（I2> 75%）。亚组分析显示，在3T和7T下进行的研究之间患者水平患病率存在显著差异（p = 0.0312）。荟萃回归分析还显示，病变水平患病率在年龄（p = 0.0018，R2 = 0.20）和疾病持续时间（p = 0.0018，R2 = 0.48）方面存在显著差异。其他主持人分析显示，根据MRI序列、性别和扩展残疾状态量表（EDSS），无显著差异。在这项研究中，我们表明，顺磁边缘病变可能存在于一个重要比例的MS患者，尽管在他们的评估跨研究的显着变化。鉴于其可能的临床相关性，我们认为应引入明确的指南，以在各研究中心之间进行评估，从而促进未来的分析。
Recent findings from several studies have shown that paramagnetic rim lesions identified using susceptibility-based MRI could represent potential diagnostic and prognostic biomarkers in multiple sclerosis (MS). Here, we perform a systematic review and meta-analysis of the existing literature to assess their pooled prevalence at lesion-level and patient-level. Both database searching (PubMed and Embase) and handsearching were conducted to identify studies allowing the lesion-level and/or patient-level prevalence of rim lesions or chronic active lesions to be calculated. Pooled prevalence was estimated using the DerSimonian-Laird random-effects model. Subgroup analysis and meta-regression were performed to explore possible sources of heterogeneity. PROSPERO registration: CRD42020192282. 29 studies comprising 1230 patients were eligible for analysis. Meta-analysis estimated pooled prevalences of 9.8% (95% CI: 6.6–14.2) and 40.6% (95% CI: 26.2–56.8) for rim lesions at lesion-level and patient-level, respectively. Pooled lesion-level and patient-level prevalences for chronic active lesions were 12.0% (95% CI: 9.0–15.8) and 64.8% (95% CI: 54.3–74.0), respectively. Considerable heterogeneity was observed across studies (I2>75%). Subgroup analysis revealed a significant difference in patient-level prevalence between studies conducted at 3T and 7T (p = 0.0312). Meta-regression analyses also showed significant differences in lesion-level prevalence with respect to age (p = 0.0018, R2 = 0.20) and disease duration (p = 0.0018, R2 = 0.48). Other moderator analyses demonstrated no significant differences according to MRI sequence, gender and expanded disability status scale (EDSS). In this study, we show that paramagnetic rim lesions may be present in an important proportion of MS patients, notwithstanding significant variation in their assessment across studies. In view of their possible clinical relevance, we believe that clear guidelines should be introduced to standardise their assessment across research centres to in turn facilitate future analyses.
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影响因子：
11.2
作者：
Maggi, Pietro;Sati, Pascal;Nair, Govind;Cortese, Irene C. M.;Jacobson, Steven;Smith, Bryan R.;Nath, Avindra;Ohayon, Joan;van Pesch, Vincent;Perrotta, Gaetano;Pot, Caroline;Theaudin, Marie;Martinelli, Vittorio;Scotti, Roberta;Wu, Tianxia;Du Pasquier, Renaud;Calabresi, Peter A.;Filippi, Massimo;Reich, Daniel S.;Absinta, Martina
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Absinta, Martina
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Huitinga I
影响因子：
3.5
作者：
Absinta, M.;Sati, P.;Reich, D. S.
通讯作者：
Reich, D. S.
影响因子：
29
作者：
Absinta, Martina;Sati, Pascal;Reich, Daniel S.
通讯作者：
Reich, Daniel S.
影响因子：
4.4
作者：
Liu, Chunlei;Li, Wei;Tong, Karen A.;Yeom, Kristen W.;Kuzminski, Samuel
通讯作者：
Kuzminski, Samuel