Factorial structure and familial aggregation of the Hypomania Checklist-32 (HCL-32): Results of the NIMH Family Study of Affective Spectrum Disorders.
Factorial structure and familial aggregation of the Hypomania Checklist-32 (HCL-32): Results of the NIMH Family Study of Affective Spectrum Disorders.
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DOI：
10.1016/j.comppsych.2018.03.010
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发表时间：
2018-07
影响因子：
7.3
通讯作者：
Merikangas KR
中科院分区：
文献类型：
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作者：
Glaus J;Van Meter A;Cui L;Marangoni C;Merikangas KR
有大量的证据表明，双相情感障碍（BD）表现在一个光谱，而不是作为一个分类条件。因此，检测具有BD的阈下表现的人是重要的。轻躁狂检查表-32（HCL-32）是作为识别此类人的工具而开发的。本文的目的是：（1）调查HCL-32的因子结构;（2）确定HCL-32是否可以区分心境障碍亚型;（3）评估轻躁狂症状的家族聚集性和交叉聚集性。从社区招募的96名先证者和他们的154名成年一级亲属完成了HCL-32。诊断基于半结构化访谈和家族史报告。使用解释性因素分析和混合效应线性回归模型。一个三因素（“活动/增加的能量”，“冒险/易怒”，“新奇寻求”）的解决方案适合HCL-32，解释11.2%的总方差。与抑郁症和无情绪障碍的患者相比，BP-I和BP-II患者的HCL冒险/易怒评分升高。HCL-32评分越高，BD-I风险越高（OR=1.22，95%CI 1.14-1.30）。“分心/易怒”评分在家庭内传播（β=0.15，p=0.040）。然而，有没有家族交叉聚集之间的情绪障碍和4 HCL因素。我们的研究结果表明，HCL-32区分情绪障碍亚型，是家族性的，并可能提供一个维度指标的倾向BD。未来的研究应该探索症状的遗传性，而不是专注于诊断。
There is substantial evidence that bipolar disorder (BD) manifests on a spectrum rather than as a categorical condition. Detection of people with subthreshold maifestations of BD is therefore important. The Hypomania Checklist-32 (HCL-32) was developed as a tool to identify such people. The aims of this paper were to: (1) investigate the factor structure of HCL-32; (2) determine whether the HCL-32 can discriminate between mood disorder subtypes; and (3) assess the familial aggregation and cross-aggregation of hypomanic symptoms assessed on the HCL with BD. Ninety-six probands recruited from the community and 154 of their adult first-degree relatives completed the HCL-32. Diagnosis was based on semi-structured interviews and family history reports. Explanatory factor analysis and mixed effects linear regression models were used. A three-factor (“Activity/Increased energy,” “Risk-taking/Irritability”, “Novelty seeking”) solution fit the HCL-32, explaining 11.2% of the total variance. The HCL Risk-taking/Irritability score was elevated among those with BP-I and BP-II, compared to those with depression and no mood disorders. Higher HCL-32 scores were associated with increased risk of BD-I (OR=1.22, 95%CI 1.14–1.30). The “Distractibility/Irritability” score was transmitted within families (β=0.15, p=0.040). However, there was no familial cross-aggregation between mood disorders and the 4 HCL factors. Our findings suggest that the HCL-32 discriminates the mood disorder subtypes, is familial and may provide a dimensional index of propensity to BD. Future studies should explore the heritability of symptoms, rather than focusing on diagnoses.
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影响因子：
--
作者：
Merikangas, KR;Stolar, M;Rounsaville, BJ
通讯作者：
Rounsaville, BJ
影响因子：
3.8
作者：
Holtmann, Martin;Poertner, Franca;Lehmkuhl, Gerd
通讯作者：
Lehmkuhl, Gerd
影响因子：
7.3
作者：
Meyer, Thomas D.;Hammelstein, Philipp;Angst, Jules
通讯作者：
Angst, Jules
影响因子：
6.6
作者：
Angst, J;Adolfsson, R;Scott, J
通讯作者：
Scott, J
DOI：
10.1017/s1121189x00006278
发表时间：
2005-04-01
期刊：
EPIDEMIOLOGIA E PSICHIATRIA SOCIALE
影响因子：
--
作者：
Angst, J;Gamma, A;Merikangas, KR
通讯作者：
Merikangas, KR