The Role of ApoE Polymorphism in the Relationship between Serum Steroid Hormone Levels and Cognition in Older Chinese Adults: A Cross-Sectional Study.
The Role of ApoE Polymorphism in the Relationship between Serum Steroid Hormone Levels and Cognition in Older Chinese Adults: A Cross-Sectional Study.
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ApoE 多态性在中国老年人血清类固醇激素水平与认知关系中的作用：一项横断面研究
DOI：
10.3389/fendo.2018.00071
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发表时间：
2018
影响因子：
5.2
通讯作者：
Yuan L
中科院分区：
文献类型：
--
作者：
Huang X;Dong S;Zhen J;Zhang H;Lin T;Zeng Y;Van Halm-Lutterodt N;Yuan L
流行病学研究表明，载脂蛋白E（ApoE）基因多态性和循环类固醇激素水平与阿尔茨海默病的风险。载脂蛋白和类固醇激素之间的生理关系表明ApoE多态性在影响老年人血清类固醇激素和认知之间的关系中起重要作用。共有500名年龄在50岁至75岁之间的中国成年人参加了这项以社区为基础的横断面研究。早晨采集血样进行ApoE基因分型和血清参数评估。通过蒙特利尔认知评估测试评估参与者的认知表现。年龄、性别、受教育程度、吸烟和体力活动水平是与中国老年人认知能力相关的因素。MCI组血清总胆固醇、高密度脂蛋白胆固醇和雌二醇水平均高于对照组（P < 0.05）。ApoE基因型血脂谱存在差异，ApoE 2和ApoE 4携带者血清甘油三酯水平明显高于对照组（P < 0.05），ApoE 4携带者血清HDL-C水平明显低于对照组（P < 0.05）。记忆力和延迟回忆能力与血清雌二醇水平有关，血清雌二醇水平越高，记忆力和延迟回忆能力越低（P < 0.05）。血清雌二醇和皮质醇浓度与认知能力的相关性是ApoE基因型依赖性的。ApoE 2和ApoE 4携带者的认知功能较差，血清雌二醇水平较高（P < 0.05）。ApoE 2和ApoE 4携带者血清皮质醇水平升高，语言能力下降（P < 0.05）。多元逻辑回归分析表明，血清雌二醇水平较高的受试者发生MCI的风险可能增加[OR = 2.004，95%置信区间（CI）：1.135，3.540; P = 0.017]。血清类固醇水平较高的ApoE 2携带者可能潜在地倾向于增加MCI的风险（OR = 3.353; 95%CI：1.135，9.907; P = 0.029）。中国老年人的认知功能与血清类固醇激素水平相关ApoE 2携带者血清类固醇水平升高可能增加老年人MCI的风险。
Epidemiology studies have indicated an association of apolipoprotein E (ApoE) genetic polymorphism and circulating steroid hormone levels with the risk of Alzheimer’s disease. The established physiologic relationship between apolipoproteins and steroid hormone indicate an important role of ApoE polymorphism in impacting the relationship between serum steroid hormones and cognition in the elderly. A total of 500 Chinese adults aged between 50 and 75 participated in this community-based cross-sectional study. Blood samples were collected in the morning for ApoE genotyping and serum parameter assessment. Cognitive performance of participants was evaluated by Montreal Cognitive Assessment test. Age, gender, educational level, smoking, and physical activity levels are factors associated with cognitive performance in this older Chinese adults. Compared to the control subjects, MCI subjects demonstrated higher serum total cholesterol, HDL-C, and estradiol status (P < 0.05). ApoE genotype difference of serum lipid profile was observed with a relatively higher mean serum triglyceride levels in ApoE2 and ApoE4 carriers (P < 0.05), and lower mean serum HDL-C level in ApoE4 carriers (P < 0.05). Memory and delayed recall ability was serum estradiol level related; and subjects with higher circulating estradiol concentration exhibited lower memory and delayed recall ability (P < 0.05). The association of serum estradiol and cortisol concentration with cognitive performance was ApoE genotypes dependent. Poor cognitive performance was observed in ApoE2 and ApoE4 carriers with higher serum estradiol level (P < 0.05). Moreover, ApoE2 and ApoE4 carriers with higher serum cortisol status demonstrated decreased language ability (P < 0.05). Multiple logistic regression analysis indicates that subjects with higher serum estradiol status may have an increased risk for MCI [OR = 2.004, 95% confidence interval (CI): 1.135, 3.540; P = 0.017]. ApoE2 carriers with higher serum steroid levels may be potentially predisposed to an increased risk of MCI (OR = 3.353; 95% CI: 1.135, 9.907; P = 0.029). Cognitive outcomes in older Chinese adults are associated with serum steroid hormone status. Higher serum steroid levels in ApoE2 carriers might pose an increased risk of MCI in the elderly.
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影响因子：
3.5
作者：
DIAMOND, DM;BENNETT, MC;ROSE, GM
通讯作者：
ROSE, GM
影响因子：
9.9
作者：
Berlau DJ;Corrada MM;Head E;Kawas CH
通讯作者：
Kawas CH
影响因子：
4.2
作者：
Engelborghs, S;Dermaut, B;De Deyn, PP
通讯作者：
De Deyn, PP
中国老年人的饮食、生活方式和认知功能。
影响因子：
4
作者：
Dong, Li;Xiao, Rong;Yuan, Linhong
通讯作者：
Yuan, Linhong
影响因子：
5.7
作者：
Bonarek, M;Barberger-Gateau, P;Dartigues, JF
通讯作者：
Dartigues, JF