Association between Cardiorespiratory Fitness and Bronchiectasis at CT: A Long-term Population-based Study of Healthy Young Adults Aged 18-30 Years in the CARDIA Study.
Association between Cardiorespiratory Fitness and Bronchiectasis at CT: A Long-term Population-based Study of Healthy Young Adults Aged 18-30 Years in the CARDIA Study.
复制标题
CT 心肺健康与支气管扩张之间的关联：CARDIA 研究中针对 18-30 岁健康年轻人的长期人群研究。
DOI：
10.1148/radiol.2021203874
复制
发表时间：
2021
期刊：
影响因子：
19.7
通讯作者：
Kalhan,Ravi
中科院分区：
文献类型：
--
作者：
Diaz,AlejandroA;Colangelo,LauraA;Okajima,Yuka;Yen,Andrew;Sala,MarcA;Dransfield,MarkT;Tino,Gregory;Ross,JamesC;SanJoséEstépar,Raúl;Washko,GeorgeR;Kalhan,Ravi
背景支气管扩张症的保护因素尚不清楚。高水平的心肺适应性与慢性阻塞性肺疾病的风险较低相关。但健身是否与支气管扩张症仍然是，知识的作者，unknown.PurposeTo检查心肺功能和bronchiectasis.Materials和MethodsThis之间的关联是一个前瞻性的观察性研究的二次分析：冠状动脉风险发展的年轻人队列（从1985-1986年[0年]到2015-2016年[30年]）。在30年期间，健康参与者（入组时年龄为18-30岁）在第0年和第20年访视时接受了跑步机运动测试。根据跑台运动持续时间确定呼吸适应性。心肺适能的20年差异被用作适能测量。在第25年，进行胸部CT以评估支气管扩张，并将其用作主要结局。多变量Logistic模型进行，以确定心肺功能的变化和bronchiectasis.ResultsOf 2177选定的参与者（在0年：平均年龄，25岁± 4 [标准差]; 1224名妇女）之间的关联，209（9.6%）在25年有支气管扩张。在校正年龄、种族-性别组、研究地点、体重指数、吸烟包年数、结核病、肺炎、哮喘和心肌梗死病史、肺功能峰值和基线时的心肺功能后，25年CT检查时，心肺功能的保持与支气管扩张的几率较低相关（从第0年到第20年，跑步机持续时间每延长1分钟：比值比[OR]，0.88; 95% CI：0.80，0.98;P= 0.02）。当支气管扩张包括咳嗽和痰时，发现了一致的强相关性（OR，0.72; 95%CI：0.59，0.87;P<0.001）。结论在长期随访中，心肺功能的保持与CT检查时支气管扩张的几率较低相关。
BackgroundProtective factors against the risk of bronchiectasis are unknown. A high level of cardiorespiratory fitness is associated with a lower risk of chronic obstructive pulmonary disease. But whether fitness relates to bronchiectasis remains, to the knowledge of the authors, unknown.PurposeTo examine the association between cardiorespiratory fitness and bronchiectasis.Materials and MethodsThis was a secondary analysis of a prospective observational study: the Coronary Artery Risk Development in Young Adults cohort (from 1985–1986 [year 0] to 2015–2016 [year 30]). During a 30-year period, healthy participants (age at enrollment 18–30 years) underwent treadmill exercise testing at year 0 and year 20 visits. Cardiorespiratory fitness was determined according to the treadmill exercise duration. The 20-year difference in cardiorespiratory fitness was used as the fitness measurement. At year 25, chest CT was performed to assess bronchiectasis and was used as the primary outcome. Multivariable logistic models were performed to determine the association between cardiorespiratory fitness changes and bronchiectasis.ResultsOf 2177 selected participants (at year 0: mean age, 25 years ± 4 [standard deviation]; 1224 women), 209 (9.6%) had bronchiectasis at year 25. After adjusting for age, race-sex group, study site, body mass index, pack-years smoked, history of tuberculosis, pneumonia, asthma and myocardial infarction, peak lung function, and cardiorespiratory fitness at baseline, preservation of cardiorespiratory fitness was associated with lower odds of bronchiectasis at CT at year 25 (per 1-minute–longer treadmill duration from year 0 to year 20: odds ratio [OR], 0.88; 95% CI: 0.80, 0.98;P= .02). A consistent strong association was found when cough and phlegm were included in bronchiectasis (OR, 0.72; 95% CI: 0.59, 0.87;P< .001).ConclusionIn a long-term follow-up, the preservation of cardiorespiratory fitness was associated with lower odds of bronchiectasis at CT.© RSNA, 2021See also the editorial by Stojanovska in this issue.
登录
查看更多内容
戒烟方法的回顾和评估：美国和加拿大，1978-1985
DOI：
--
发表时间：
1987
期刊：
影响因子：
--
作者：
J. L. Schwartz
通讯作者：
J. L. Schwartz
评估将尼古丁口香糖与自我指导行为治疗相结合以预防吸烟复吸的治疗方法。
影响因子：
5.9
作者：
Killen,JD;Fortmann,SP;Newman,B;Varady,A
通讯作者：
Varady,A
吸烟和肥胖的累犯和自愈。
影响因子：
16.4
作者：
S. Schachter
通讯作者：
S. Schachter
影响因子：
8
作者：
J. Hughes;S. Higgins;D. Hatsukami
通讯作者：
D. Hatsukami
DOI：
10.1037//0003-066x.44.11.1355
发表时间：
1989
期刊：
The American psychologist
影响因子：
--
作者：
Cohen,S;Lichtenstein,E;Prochaska,JO;Rossi,JS;Gritz,ER;Carr,CR;Orleans,CT;Schoenbach,VJ;Biener,L;Abrams,D
通讯作者：
Abrams,D