Molecular and Therapeutic Aspects of Hyperbaric Oxygen Therapy in Neurological Conditions.

Molecular and Therapeutic Aspects of Hyperbaric Oxygen Therapy in Neurological Conditions.
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DOI:
10.3390/biom10091247
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发表时间:
2020-08-27
期刊:
影响因子:
5.5
通讯作者:
Barak B
Barak B
中科院分区:
生物学2区
文献类型:
--
作者:
Fischer I;Barak B

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在高压氧治疗(HBOT)中,受试者被放置在一个含有100%氧气的室中,压力大于一个大气压。这种治疗通过向受损组织提供更多的氧气供应来加速组织恢复并改善其生理方面。在这篇综述中,我们讨论了缺氧的后果,以及暴露于HBOT的受试者发生的分子和生理过程。我们在人类和动物模型中讨论了HBOT治疗神经系统疾病和神经发育障碍的疗效。我们通过讨论该领域的挑战进行总结,并探索未来的方向,这将使科学界更好地了解HBOT在各种神经系统疾病中的分子方面和应用。
In hyperbaric oxygen therapy (HBOT), the subject is placed in a chamber containing 100% oxygen gas at a pressure of more than one atmosphere absolute. This treatment is used to hasten tissue recovery and improve its physiological aspects, by providing an increased supply of oxygen to the damaged tissue. In this review, we discuss the consequences of hypoxia, as well as the molecular and physiological processes that occur in subjects exposed to HBOT. We discuss the efficacy of HBOT in treating neurological conditions and neurodevelopmental disorders in both humans and animal models. We summarize by discussing the challenges in this field, and explore future directions that will allow the scientific community to better understand the molecular aspects and applications of HBOT for a wide variety of neurological conditions.
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