Identifying a clinically meaningful threshold for change in uveitic macular edema evaluated by optical coherence tomography.
Identifying a clinically meaningful threshold for change in uveitic macular edema evaluated by optical coherence tomography.
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DOI：
10.1016/j.ajo.2011.05.028
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发表时间：
2011-12
影响因子：
4.2
通讯作者：
Thorne, Jennifer E.
中科院分区：
文献类型：
--
作者：
Sugar, Elizabeth A.;Jabs, Douglas A.;Altaweel, Michael M.;Lightman, Sue;Acharya, Nisha;Vitale, Albert T.;Thorne, Jennifer E.
利用与视力变化的相关性，确定通过光学相干断层扫描 (OCT) 测量葡萄膜炎性黄斑水肿患者视网膜厚度变化的有临床意义的阈值。横断面和纵向研究。 128 只患有黄斑水肿的眼睛（101 人）参加了多中心葡萄膜炎类固醇治疗 (MUST) 试验。在入组时和六个月随访后，使用时域 OCT 测量中央子视野的视网膜厚度，并使用对数 (ETDRS) 视力表测量视力。如果视网膜厚度≥260μm，则参与者被归类为黄斑水肿。视网膜中心子区域厚度变化的阈值为 20%，平衡了预测视力超过 10 个字母变化的假阳性和阴性百分比，灵敏度为 77%，特异性为 75%。对于超过 5 个或 15 个或更多字母更改，结果相似。视网膜厚度减少 20% 或以上的患者的视力平均提高了 11.0 个字母（95% CI：7.7 至 14.3），而那些视网膜厚度没有减少 20% 的患者的视力变化为 -0.4 个字母（95% CI：-4.1 至 3.3）（p < 0.01）。除了高于测量不确定度水平之外，黄斑水肿患者的视网膜厚度变化 20% 似乎对于视力的临床重要变化是最佳的，并且可以被视为葡萄膜炎黄斑水肿治疗临床试验的结果。
To identify a clinically meaningful threshold for change in retinal thickness measured by optical coherence tomography (OCT) for patients with uveitic macular edema, using correlation with change in visual acuity. Cross-sectional and longitudinal study. 128 eyes (101 individuals) with macular edema enrolled in the Multicenter Uveitis Steroid Treatment (MUST) trial. At enrollment and after six months of follow-up, retinal thickness was measured at the central subfield with time domain OCT and visual acuity was measured with logarithmic (ETDRS) visual acuity charts. Participants were classified as having macular edema if the retinal thickness was ≥260μm. A threshold for change in retinal center subfield thickness of 20% balanced the percentage of false positives and negatives for predicting greater than 10-letter change in visual acuity with sensitivity of 77% and a specificity of 75%. The results were similar for greater than 5 or 15 or greater letter changes. Those with a 20% or greater reduction in retinal thickness had a mean 11.0 letter improvement (95% CI: 7.7 to 14.3) as compared to a -0.4 letter change (95% CI: -4.1 to 3.3) in visual acuity for those without a 20% reduction (p < 0.01). In addition to being above the level of measurement uncertainty, a 20% change in retinal thickness in patients with macular edema appears to be optimal for clinically important changes in visual acuity and may be considered as an outcome for clinical trials of treatments for uveitic macular edema.
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影响因子：
--
作者：
Chan, A;Duker, JS;Schuman, JS
通讯作者：
Schuman, JS
影响因子：
--
作者：
Callanan, David G.;Jaffe, Glenn J.;Comstock, Timothy L.
通讯作者：
Comstock, Timothy L.
影响因子：
2.1
作者：
Dai, James Y.;Ruczinski, Ingo;Kooperberg, Charles
通讯作者：
Kooperberg, Charles
DOI：
10.1097/iae.0b013e318169d04e
发表时间：
2008-06-01
影响因子：
3.3
作者：
Kim, Stephen J.;Belair, Marie-Lyne;Jabs, Douglas A.
通讯作者：
Jabs, Douglas A.
影响因子：
0.7
作者：
Nagasawa, Toshihiko;Naito, Takeshi;Shiota, Hiroshi
通讯作者：
Shiota, Hiroshi