Associations of FTO and MC4R Variants with Obesity Traits in Indians and the Role of Rural/Urban Environment as a Possible Effect Modifier.
Associations of FTO and MC4R Variants with Obesity Traits in Indians and the Role of Rural/Urban Environment as a Possible Effect Modifier.
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DOI：
10.1155/2011/307542
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发表时间：
2011
影响因子：
3.3
通讯作者：
Chandak GR
中科院分区：
文献类型：
--
作者：
Taylor AE;Sandeep MN;Janipalli CS;Giambartolomei C;Evans DM;Kranthi Kumar MV;Vinay DG;Smitha P;Gupta V;Aruna M;Kinra S;Sullivan RM;Bowen L;Timpson NJ;Davey Smith G;Dudbridge F;Prabhakaran D;Ben-Shlomo Y;Reddy KS;Ebrahim S;Chandak GR
很少有研究调查印度人群中的遗传变异和肥胖特征之间的联系，或者环境因素作为这些关系的修饰者的作用。在快速城市化的背景下，导致生活方式的重大变化，了解肥胖的病因学是重要的。我们调查了来自印度四个城市的3390对兄弟姐妹中FTO和MC4R变异与肥胖特征的关系，其中大多数人与当前居住的城市(农村或城市)不协调。FTO变异rs9939609预测体重(0.09 Z分，95%CI：0.03，0.15)和体重指数(0.08 Z分，95%CI：0.02，0.14)增加。MC4R变异rs17782313与体重和臀围的相关性较弱(P<；0.05)。有一些迹象表明，FTO和体重之间的关联在城市居民中比在农村居民中更强(交互作用P=0.03)，但没有证据表明饮食或体力活动的影响。需要进一步的研究来调查城市环境可能改变肥胖遗传风险的方式。
Few studies have investigated the association between genetic variation and obesity traits in Indian populations or the role of environmental factors as modifiers of these relationships. In the context of rapid urbanisation, resulting in significant lifestyle changes, understanding the aetiology of obesity is important. We investigated associations of FTO and MC4R variants with obesity traits in 3390 sibling pairs from four Indian cities, most of whom were discordant for current dwelling (rural or urban). The FTO variant rs9939609 predicted increased weight (0.09 Z-scores, 95% CI: 0.03, 0.15) and BMI (0.08 Z-scores, 95% CI: 0.02, 0.14). The MC4R variant rs17782313 was weakly associated with weight and hip circumference (P < .05). There was some indication that the association between FTO and weight was stronger in urban than that in rural dwellers (P for interaction = .03), but no evidence for effect modification by diet or physical activity. Further studies are needed to investigate ways in which urban environment may modify genetic risk of obesity.
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影响因子：
158.5
作者：
Cecil, Joanne E.;Tavendale, Roger;Palmer, Colin N. A.
通讯作者：
Palmer, Colin N. A.
影响因子：
30.8
作者：
通讯作者：
--
影响因子：
30.8
作者：
通讯作者：
--
影响因子：
4.5
作者：
Heard-Costa NL;Zillikens MC;Monda KL;Johansson A;Harris TB;Fu M;Haritunians T;Feitosa MF;Aspelund T;Eiriksdottir G;Garcia M;Launer LJ;Smith AV;Mitchell BD;McArdle PF;Shuldiner AR;Bielinski SJ;Boerwinkle E;Brancati F;Demerath EW;Pankow JS;Arnold AM;Chen YD;Glazer NL;McKnight B;Psaty BM;Rotter JI;Amin N;Campbell H;Gyllensten U;Pattaro C;Pramstaller PP;Rudan I;Struchalin M;Vitart V;Gao X;Kraja A;Province MA;Zhang Q;Atwood LD;Dupuis J;Hirschhorn JN;Jaquish CE;O'Donnell CJ;Vasan RS;White CC;Aulchenko YS;Estrada K;Hofman A;Rivadeneira F;Uitterlinden AG;Witteman JC;Oostra BA;Kaplan RC;Gudnason V;O'Connell JR;Borecki IB;van Duijn CM;Cupples LA;Fox CS;North KE
通讯作者：
North KE
影响因子：
30.8
作者：
Chambers, John C.;Elliott, Paul;Kooner, Jaspal S.
通讯作者：
Kooner, Jaspal S.