Onset of alcohol or substance use disorders following treatment for adolescent depression.
Onset of alcohol or substance use disorders following treatment for adolescent depression.
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DOI：
10.1037/a0026929
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发表时间：
2012-04
影响因子：
5.9
通讯作者：
March, John
中科院分区：
文献类型：
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作者：
Curry, John;Silva, Susan;Rohde, Paul;Ginsburg, Golda;Kennard, Betsy;Kratochvil, Christopher;Simons, Anne;Kirchner, Jerry;May, Diane;Mayes, Taryn;Feeny, Norah;Albano, Anne Marie;Lavanier, Sarah;Reinecke, Mark;Jacobs, Rachel;Becker-Weidman, Emily;Weller, Elizabeth;Emslie, Graham;Walkup, John;Kastelic, Elizabeth;Burns, Barbara;Wells, Karen;March, John
这项研究测试了对青少年严重抑郁障碍(MDD)的短期治疗的积极反应是否会有预防随后的酒精或药物使用障碍的次要好处。我们对192名青少年(女性56.2%，少数民族20.8%)进行了五年的跟踪调查，他们参加了青少年抑郁症治疗研究(TADS)，并且以前没有酒精或药物使用障碍的诊断。TADS的初始治疗包括认知行为疗法(CBT)、氟西汀(Floxetine)、CBT与Flx的联合治疗(COMB)或临床用药安慰剂(PBO)。我们使用了最初的TADS治疗反应评分和更具限制性的症状计数评分。在随访期间，每隔6个月或12个月完成诊断性访谈，以评估酒精(AUD)或物质使用障碍(SUD)的发病、MDD的恢复和复发。对MDD治疗取得阳性反应与随后的AUD无关，但无论阳性反应的衡量标准如何，预测后续SUD的发生率较低(分别为11.65%对24.72%；或10.0%对24.5%)。初始MDD治疗的类型与这两种结果均无关。在抑郁症治疗之前，更多地接触酒精或药物预示着以后会出现酒精或物质使用障碍，年龄较大(对于AUD)和更多共病障碍(对于SUD)也是如此。在复发的MDD和AUD患者中，25例中有24例AUD先于MDD复发。有效的短期青少年抑郁症治疗显著减少了随后的药物使用，但不是酒精使用，障碍的发生率。酒精或药物的使用应在青少年MDD治疗之前进行评估，并在MDD康复后进行监测。
This study tested whether positive response to short-term treatment for adolescent major depressive disorder (MDD) would have the secondary benefit of preventing subsequent alcohol or substance use disorders. We followed for five years 192 adolescents (56.2% female; 20.8% minority) who had participated in the Treatment for Adolescents with Depression Study (TADS), and had no prior diagnoses of alcohol or substance use disorders. TADS initial treatments were cognitive behavior therapy (CBT), fluoxetine (FLX), the combination of CBT and FLX (COMB), or clinical management with pill placebo (PBO). We used both the original TADS treatment response rating and a more restrictive symptom count rating. During follow-up, diagnostic interviews were completed at six or 12 month intervals to assess onset of alcohol (AUD) or substance use disorders (SUD), MDD recovery and recurrence. Achieving a positive response to MDD treatment was unrelated to subsequent AUD, but predicted lower rate of subsequent SUD, regardless of the measure of positive response (11.65% versus 24.72%; or 10.0% versus 24.5%, respectively). Type of initial MDD treatment was not related to either outcome. Prior to depression treatment, greater involvement with alcohol or drugs predicted later alcohol or substance use disorders, as did older age (for AUD) and more comorbid disorders (for SUD). Among those with recurrent MDD and AUD, AUD preceded MDD recurrence in 24 of 25 cases. Effective short-term adolescent depression treatment significantly reduces the rate of subsequent substance use, but not alcohol use, disorders. Alcohol or drug use should be assessed prior to adolescent MDD treatment and monitored even after MDD recovery.
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影响因子：
12.7
作者：
DEYKIN, EY;LEVY, JC;WELLS, V
通讯作者：
WELLS, V
影响因子：
6.9
作者：
Glantz, M. D.;Anthony, J. C.;Berglund, P. A.;Degenhardt, L.;Dierker, L.;Kalaydjian, A.;Merikangas, K. R.;Ruscio, A. M.;Swendsens, J.;Kessler, R. C.
通讯作者：
Kessler, R. C.
影响因子：
--
作者：
Hasin, D;Liu, XH;Endicott, J
通讯作者：
Endicott, J
影响因子：
4.6
作者：
Chassin, L;Pitts, SC;Todd, M
通讯作者：
Todd, M
DOI：
10.1207/s15374424jccp280302
发表时间：
1999-09-01
期刊：
JOURNAL OF CLINICAL CHILD PSYCHOLOGY
影响因子：
--
作者：
Costello, EJ;Erkanli, A;Angold, A
通讯作者：
Angold, A