Polypeptide growth factors in bone matrix.
Polypeptide growth factors in bone matrix.
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骨基质中的多肽生长因子。
DOI：
10.1002/9780470513637.ch13
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Mavrakos,AE
中科院分区：
文献类型：
--
作者：
Hauschka,PV;Chen,TL;Mavrakos,AE
现已证实，骨的矿化细胞外基质中存在多种多肽生长因子。这些因子通常被称为骨源性生长因子（BDGF），与以下物种相似或可能相同：血小板源性生长因子（PDGF）;酸性和碱性形式的成纤维细胞生长因子（aFGF，bFGF）;转化生长因子β（TGF-β）;和胰岛素样生长因子1（IGF-1）。还鉴定了几种骨诱导因子，如骨形态发生蛋白（BMP）和成骨素、骨骼生长因子（SGF）和成骨细胞源性BDGF。这些与骨相关的BDGF的生物学功能的完整描述最终将需要涉及特定细胞类型的体外特定生物测定，以及体内动物植入模型。原代大鼠成骨细胞样细胞暴露于混合BDGF、纯TGF-β或肝素纯化的PDGF、aFGF或牛骨bFGF的研究显示了一般的剂量依赖性促有丝分裂效应。伴随BDGF诱导的增殖波的表型变化包括：骨钙素分泌减少和1，25-（OH）、维生素D3刺激的骨钙素合成减少;碱性磷酸酶比活性降低;环AMP对甲状旁腺激素（PTH）的反应性降低;胶原合成增加。骨显示出迄今所描述的任何组织中最复杂的生长因子活性谱。在不含血液和软骨污染的牛骨粉中，有丝分裂原的体积浓度比血清中高出20倍。骨细胞和其他固有细胞类型必须被认为是BDGF的可能来源，除了从血液中隔离。BDGF从矿化基质中暴露或释放的机制导致对成骨细胞、内皮细胞和其他靶细胞的局部作用，这对于骨组织的发育和维持无疑是重要的。
The presence of many types of polypeptide growth factors in the mineralized extracellular matrix of bone is now well established. These factors are generally referred to as bone‐derived growth factors (BDGFs), and are similar, or possibly identical, to the following species; platelet‐derived growth factor (PDGF); acidic and basic forms of fibroblast growth factor (aFGF, bFGF); transforming growth factor β (TGF‐β); and insulin‐like growth factor 1 (IGF‐1). Several osteoinductive factors, such as bone morphogenetic protein (BMP) and osteogenin, a skeletal growth factor (SGF), and osteoblast‐derived BDGFs, have also been identified. Complete description of the biological functions of these BDGFs which are relevant to bone will ultimately require specific bioassays involving specific cell typesin vitro, as well asin vivoanimal implant models. Studies with primary rat osteoblast‐like cells exposed either to mixed BDGFs, pure TGF‐β, or heparin‐purified PDGF, aFGF, or bFGF from bovine bone have shown a general dose‐dependent mitogenic effect. Phenotypic changes which accompany the BDGF‐induced wave of proliferation include: decreased osteocalcin secretion and a reduction in 1,25‐(OH), vitamin D3‐stimulated osteocalcin synthesis; reduced alkaline phosphatase specific activity; decreased cyclic AMP responsiveness to parathyroid hormone (PTH); and increased collagen synthesis. Bone exhibits the most complex spectrum of growth factor activities of any tissue yet described. In bovine bone powder free of blood and cartilage contamination, the volume concentration of mitogens is up to 20 times greater than that in serum. Bone cells and other indigenous cell types must be considered as possible sources of the BDGFs, in addition to sequestration from blood. Mechanisms for the unmasking or release of BDGFs from the mineralized matrix that result in local action on osteoblasts, endothelial cells, and other target cells are undoubtedly important for the development and maintenance of bone tissue.
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用于成骨细胞样细胞和软骨细胞的巨噬细胞衍生生长因子。
DOI：
--
发表时间：
1984
影响因子：
11.1
作者：
L. Rifas;V. Shen;K. Mitchell;W. Peck
通讯作者：
W. Peck
影响因子：
2.9
作者：
Farley,JR;Baylink,DJ
通讯作者：
Baylink,DJ
通过肝素亲和层析纯化软骨源性生长因子。
DOI：
--
发表时间：
1985
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Sullivan,R;Klagsbrun,M
通讯作者：
Klagsbrun,M
血小板衍生生长因子对培养的大鼠颅盖细胞的生长控制。
DOI：
--
发表时间：
1986
期刊：
Journal of oral pathology
影响因子：
--
作者：
C. T. Hanks;J.;C. Edwards
通讯作者：
C. Edwards
影响因子：
15.9
作者：
DEUEL, TF;SENIOR, RM;HUANG, JS
通讯作者：
HUANG, JS