Assessment of feeding behavior in laboratory mice.

Assessment of feeding behavior in laboratory mice.
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DOI:
10.1016/j.cmet.2010.06.001
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发表时间:
2010-07-07
期刊:
影响因子:
29
通讯作者:
Schwartz MW
Schwartz MW
中科院分区:
生物学1区
文献类型:
--
作者:
Ellacott KL;Morton GJ;Woods SC;Tso P;Schwartz MW

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全球肥胖症的流行加剧了对如何控制体重的更好理解的需要,而使用小鼠模型的研究对这一努力至关重要。从这个角度来看,我们提供了一个概念框架,在这个物种的摄食行为的调查,重点是影响研究设计,数据解释和相关性在人类摄食行为的因素。虽然我们专注于小鼠,但所提出的原则可以应用于大多数其他动物模型。本文件代表了美国国立卫生研究院(NIH)资助的小鼠代谢表型中心(MMPC)研究人员目前的共识。
The global obesity epidemic has heightened the need for an improved understanding of how body weight is controlled, and research using mouse models is critical to this effort. In this perspective, we provide a conceptual framework for investigation of feeding behavior in this species, with an emphasis on factors that influence study design, data interpretation, and relevance to feeding behavior in humans. Although we focus on the mouse, the principles presented can be applied to most other animal models. This document represents the current consensus view of investigators from the National Institutes of Health (NIH)-funded Mouse Metabolic Phenotyping Centers (MMPCs).
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