Consumption of fermented milk product with probiotic modulates brain activity.
Consumption of fermented milk product with probiotic modulates brain activity.
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DOI：
10.1053/j.gastro.2013.02.043
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发表时间：
2013-06
期刊：
影响因子：
29.4
通讯作者：
Mayer EA
中科院分区：
文献类型：
--
作者：
Tillisch K;Labus J;Kilpatrick L;Jiang Z;Stains J;Ebrat B;Guyonnet D;Legrain-Raspaud S;Trotin B;Naliboff B;Mayer EA
据报道，肠道微生物群的变化会改变啮齿动物的信号传导机制、情绪行为和内脏伤害性反射。然而，用抗生素或益生菌改变肠道微生物群并没有显示出在人类中产生这些变化。我们调查了健康女性食用含有益生菌的发酵乳制品（FMPP）4周是否会改变大脑内在连接或对情绪注意力任务的反应。没有胃肠道或精神症状的健康女性被随机分配到给予FMPP（n = 12），非发酵乳制品（n = 11，对照）或无干预（n = 13）组，每天两次，持续4周。FMPP含有动物双歧杆菌乳酸亚种、嗜热链球菌、保加利亚乳杆菌和乳酸乳球菌乳酸亚种。参与者在干预前后进行了功能性磁共振成像，以测量大脑对情绪面部注意力任务的反应和休息时的大脑活动。进行了多变量和感兴趣区域分析。FMPP摄入与分布式功能网络（49%交叉块协方差; P = 0.004）的任务相关反应降低相关，该网络包含情感、内脏感觉和躯体感觉皮层。静息脑内在活动的改变表明，摄入FMPP与中脑连接的变化有关，这可以解释在任务期间观察到的活动差异。健康女性摄入FMPP四周后，控制情绪和感觉中枢处理的大脑区域的活动受到影响。
Changes in gut microbiota have been reported to alter signaling mechanisms, emotional behavior, and visceral nociceptive reflexes in rodents. However, alteration of the intestinal microbiota with antibiotics or probiotics has not been shown to produce these changes in humans. We investigated whether consumption of a fermented milk product with probiotic (FMPP) for 4 weeks by healthy women altered brain intrinsic connectivity or responses to emotional attention tasks. Healthy women with no gastrointestinal or psychiatric symptoms were randomly assigned to groups given FMPP (n = 12), a nonfermented milk product (n = 11, controls), or no intervention (n = 13) twice daily for 4 weeks. The FMPP contained Bifidobacterium animalis subsp Lactis, Streptococcus thermophiles, Lactobacillus bulgaricus, and Lactococcus lactis subsp Lactis. Participants underwent functional magnetic resonance imaging before and after the intervention to measure brain response to an emotional faces attention task and resting brain activity. Multivariate and region of interest analyses were performed. FMPP intake was associated with reduced task-related response of a distributed functional network (49% cross-block covariance; P = .004) containing affective, viscerosensory, and somatosensory cortices. Alterations in intrinsic activity of resting brain indicated that ingestion of FMPP was associated with changes in midbrain connectivity, which could explain the observed differences in activity during the task. Four-week intake of an FMPP by healthy women affected activity of brain regions that control central processing of emotion and sensation.
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DOI：
10.1073/pnas.0711891105
发表时间：
2008-02-12
影响因子：
11.1
作者：
Amaral, F. A.;Sachs, D.;Teixeira, M. M.
通讯作者：
Teixeira, M. M.
影响因子：
4.2
作者：
Eutamene, Helene;Lamine, Florence;Bueno, Lionel
通讯作者：
Bueno, Lionel
影响因子：
7.6
作者：
Agrawal, A.;Houghton, L. A.;Whorwell, P. J.
通讯作者：
Whorwell, P. J.
影响因子：
3.5
作者：
Ait-Belgnaoui, A.;Eutamene, H.;Theodorou, V.
通讯作者：
Theodorou, V.
影响因子：
5.7
作者：
Britton, Jennifer C.;Taylor, Stephan F.;Liberzon, Israel
通讯作者：
Liberzon, Israel