Impact of vaccination on the symptoms of hospitalised patients with SARS-CoV-2 Delta variant (B.1.617.1) infection.
Impact of vaccination on the symptoms of hospitalised patients with SARS-CoV-2 Delta variant (B.1.617.1) infection.
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DOI：
10.1016/j.cmi.2022.06.019
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发表时间：
2022-12
影响因子：
14.2
通讯作者：
Beraud, Guillaume
中科院分区：
文献类型：
--
作者：
Epaulard, Olivier;Abgrall, Sophie;Lefebvre, Maeva;Faucher, Jean-Francois;Michon, Jocelyn;Frentiu, Emilia;Blanchi, Sophie;Janssen, Cecile;Charbonnier, Gabrielle;Fresse, Audrey;Laurent, Simon;Sandjakian, Lena;Casez, Pierre;Mahamat, Aba;Beraud, Guillaume
初次接种后，SARS-CoV-2 δ (B.1.617.2)变异的扩散和免疫应答的减弱有利于接种者SARS-CoV-2的突破性感染。为了评估疫苗接种的影响，我们根据疫苗接种情况确定住院患者感染的严重程度。我们对2021年7月至11月在10个中心因SARS-CoV-2感染（德尔塔变体）住院的患者进行了回顾性观察研究，包括所有在入院前至少14天完成初次疫苗接种的患者和相同数量的完全未接种疫苗的患者。我们通过逻辑回归评估疫苗接种和其他危险因素的影响。我们纳入了955例患者（474例接种疫苗，481例未接种疫苗）。接种疫苗的患者明显年龄较大（75.0[63.25-84.0]比55.0 [38.0-73.0],p < 0.001），男性较多(55.1%（261/474）比46.4% (223/481)；p = 0.009),有更多的并发症(2.0(1.0 - -3.0)和1.0 (0.0 - -2.0),p < 0.001)。接种疫苗的患者因Covid-19入院的次数较少(59.3%（281/474）对75.1% (361/481)；P < 0.001)，肺部扩展病变较少(≤25%:64.3% (117/182)vs. 38.4% (88/229)；P < 0.001)，需氧量较少(57.5% (229/398)vs. 73.0% (270/370)；p < 0.001),以较低的流(3.0(0.0 - -8.7)和6.0 (2.0 - -50.0)L / min, p < 0.001),在短时间内(3(0.0 - -8.0)和6(2.0 - -12.0)天,p < 0.001)。重症监护病房入院次数较少(16.2% (60/370)vs. 36.0% (133/369)；P < 0.001)，但在双变量分析中死亡率相当(16.7%（74/443）对12.2% (53/433)；p = 0.075)。多因素logistic回归显示，接种疫苗显著降低死亡风险(0.38 [0.20-0.70]（p = 0.002）、ICU入院风险(0.31 [0.21-0.47]（p < 0.001）和需氧量(0.16 [0.10-0.26](p < 0.001)，即使在老年患者或合并合并症患者中也是如此。在因δ型SARS-CoV-2感染住院的患者中，即使存在合并症，接种疫苗也与较不严重的形式相关。
The diffusion of the SARS-CoV-2 Delta (B.1.617.2) variant and the waning of immune response after primary Covid-19 vaccination favoured the breakthrough SARS-CoV-2 infections in vaccinated subjects. To assess the impact of vaccination, we determined the severity of infection in hospitalised patients according to vaccine status. We performed a retrospective observational study on patients hospitalised in 10 centres with a SARS-CoV-2 infection (Delta variant) from July to November 2021 by including all patients who had completed their primary vaccination at least 14 days before hospital admission and the same number of completely unvaccinated patients. We assessed the impact of vaccination and other risk factors through logistic regression. We included 955 patients (474 vaccinated and 481 unvaccinated). Vaccinated patients were significantly older (75.0 [63.25-84.0] vs. 55.0 [38.0-73.0]; p < 0.001), more frequently males (55.1% (261/474) vs. 46.4% (223/481); p = 0.009), and had more comorbidities (2.0 [1.0-3.0] vs. 1.0 [0.0-2.0]; p < 0.001). Vaccinated patients were less often admitted for Covid-19 (59.3% (281/474) vs. 75.1% (361/481); p < 0.001), had less extended lung lesions (≤25%: 64.3% (117/182) vs. 38.4% (88/229); p < 0.001), required oxygen less frequently (57.5% (229/398) vs. 73.0% (270/370); p < 0.001), at a lower flow (3.0 [0.0-8.7] vs. 6.0 [2.0-50.0] L/min, p < 0.001), and for a shorter duration (3 [0.0-8.0] vs. 6 [2.0-12.0] days, p < 0.001)., and required less frequently intensive care unit admission (16.2% (60/370) vs. 36.0% (133/369); p < 0.001) but had comparable mortality in bivariate analysis (16.7% (74/443) vs. 12.2% (53/433); p = 0.075). Multivariate logistic regression showed that vaccination significantly decreased the risk of death (0.38 [0.20-0.70](p = 0.002), ICU admission (0.31 [0.21-0.47](p < 0.001) and oxygen requirement (0.16 [0.10-0.26](p < 0.001), even among older patients or with comorbidities. Among patients hospitalised with a delta variant SARS-CoV-2 infection, vaccination was associated with less severe forms, even in the presence of comorbidities.
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影响因子：
4
作者：
Jakobsen JC;Gluud C;Wetterslev J;Winkel P
通讯作者：
Winkel P
DOI：
10.1016/j.cmi.2021.12.013
发表时间：
2022-04
期刊：
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
影响因子：
--
作者：
Pierobon A;Zotto AD;Antico A;De Antoni ME;Vianello L;Gennari M;Di Caprio A;Russo F;Brambilla G;Saugo M
通讯作者：
Saugo M
影响因子：
11.8
作者：
Bosch, Wendelyn;Cowart, Jennifer B.;Moreno Franco, Pablo
通讯作者：
Moreno Franco, Pablo
DOI：
10.2807/1560-7917.es.2022.27.9.2200121
发表时间：
2022-03
期刊：
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin
影响因子：
--
作者：
Kahn F;Bonander C;Moghaddassi M;Rasmussen M;Malmqvist U;Inghammar M;Björk J
通讯作者：
Björk J
DOI：
10.2807/1560-7917.es.2021.26.41.2100920
发表时间：
2021-10
期刊：
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin
影响因子：
--
作者：
Harder T;Külper-Schiek W;Reda S;Treskova-Schwarzbach M;Koch J;Vygen-Bonnet S;Wichmann O
通讯作者：
Wichmann O