A Connectome-wide Functional Signature of Trait Anger.

A Connectome-wide Functional Signature of Trait Anger.
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DOI:
10.1177/21677026211030240
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发表时间:
2022-05
影响因子:
4.8
通讯作者:
Hariri, Ahmad R.
Hariri, Ahmad R.
中科院分区:
医学1区
文献类型:
--
作者:
Kim, M. Justin;Elliott, Maxwell L.;Knodt, Annchen R.;Hariri, Ahmad R.

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过去对特质愤怒的大脑相关性的研究受到样本量小,关注相对较少的感兴趣区域以及功能性大脑测量的重测信度差的限制。为了解决这些局限性,我们在1,048名年轻成年志愿者的样本中对连接体范围功能连接的变异性进行了数据驱动分析。多维矩阵回归分析表明,自我报告的特质愤怒映射到三个大脑区域的全脑功能连接模式的变异性,这些大脑区域提供与动作相关的功能:双侧补充运动区(SMA)和右侧额叶。然后,我们证明特质愤怒调制这些区域的功能连接与典型的大脑网络支持somatomotor,情感,自我参照和视觉信息过程。我们的研究结果提供了新的神经影像学证据,解释特质愤怒作为一个更大的倾向,挑起行动,支持正在进行的努力,以了解其作为一个潜在的transdiagnosis标记为特征的攻击性行为的紊乱状态。
Past research on the brain correlates of trait anger has been limited by small sample sizes, a focus on relatively few regions-of-interest, and poor test-retest reliability of functional brain measures. To address these limitations, we conducted a data-driven analysis of variability in connectome-wide functional connectivity in a sample of 1,048 young adult volunteers. Multi-dimensional matrix regression analysis showed that self-reported trait anger maps onto variability in the whole-brain functional connectivity patterns of three brain regions that serve action-related functions: bilateral supplementary motor area (SMA) and the right lateral frontal pole. We then demonstrate trait anger modulates the functional connectivity of these regions with canonical brain networks supporting somatomotor, affective, self-referential, and visual information processes. Our findings offer novel neuroimaging evidence for interpreting trait anger as a greater propensity to provoked action, supporting ongoing efforts to understand its utility as a potential transdiagnostic marker for disordered states characterized by aggressive behavior.
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