Elucidation of the structure of retroviral proteases: a reminiscence.
Elucidation of the structure of retroviral proteases: a reminiscence.
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DOI：
10.1111/febs.13397
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发表时间：
2015-11
期刊：
影响因子：
--
通讯作者：
Wlodawer A
中科院分区：
文献类型：
--
作者：
Jaskolski M;Miller M;Mohana Rao JK;Gustchina A;Wlodawer A
Determinations of only a very few protein structures had consequences comparable to the impact exerted by the structure of the protease encoded by the human immunodeficiency virus type 1 (HIV-1), published just over 25 years ago. The structure of this relatively small protein and its cousins from other retroviruses provided a clear target for a spectacularly successful structure-assisted drug design effort that offered new hope for controlling the then-escalating AIDS epidemic. This reminiscence is limited primarily to work conducted at the National Cancer Institute and is not meant to be a comprehensive history of the field, but rather is an attempt to provide a very personal account of how the structures of this most thoroughly studied crystallographic target were determined.
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DOI：
10.1111/j.1742-4658.2011.08364.x
发表时间：
2011-11
期刊：
The FEBS journal
影响因子：
--
作者：
Li M;Gustchina A;Matúz K;Tözsér J;Namwong S;Goldfarb NE;Dunn BM;Wlodawer A
通讯作者：
Wlodawer A
影响因子：
56.9
作者：
BARRESINOUSSI, F;CHERMANN, JC;MONTAGNIER, L
通讯作者：
MONTAGNIER, L
影响因子：
5.6
作者：
Johnson, Erik C. B.;Malito, Enrico;Kent, Stephen B. H.
通讯作者：
Kent, Stephen B. H.
影响因子：
64.8
作者：
MILLER, M;JASKOLSKI, M;WLODAWER, A
通讯作者：
WLODAWER, A
影响因子：
3.5
作者：
RAO, JKM;WLODAWER, A
通讯作者：
WLODAWER, A