Bone Regeneration and Fracture Healing: Experience With Distraction Osteogenesis Model
Bone Regeneration and Fracture Healing: Experience With Distraction Osteogenesis Model
复制标题
骨再生和骨折愈合：牵引成骨模型的经验
DOI：
--
复制
发表时间：
1998
影响因子：
4.2
通讯作者：
S. Goldstein
中科院分区：
文献类型：
--
作者：
M. Richards;J. Goulet;J. Weiss;N. A. Waanders;M. Schaffler;S. Goldstein
物理力与骨再生和愈合过程之间的关系仍不完全清楚。对这些过程的理解存在差距，部分原因是模型产生的新骨数量不足。通过使用牵张成骨产生的骨为研究机械力及其对骨形成的影响提供了有吸引力的基底，因为该技术以受控的方式产生大量的新骨。临床上骨形成的最佳力学环境尚未完全确定。然而，在实验室研究中，可以操纵机械环境，并且可以测量骨形成的结果变化。为了研究应变环境的变化如何影响骨形成的模式，实施了双侧牵张成骨。当一个加强筋被应用到外部牵引器，计算分析预测在所有应变措施的七到八倍减少。这些间隙应变的减少似乎诱导骨体积分数和平均骨小梁厚度显著降低。当与骨轴成30°角进行截骨以在差距组织内产生更多剪切力时，观察到间隙应变分布的变化和由此产生的新骨结构。在这两个实验中，观察到组织水平应变变化与骨再生模式之间的特定相关性。这些结果提供了直接的体内证据表明，多能间隙组织是敏感的，他们的物理环境。负责这种敏感性的机制可能包括血管分布、干细胞供应和支架结构。牵张成骨中的骨形成过程似乎与更常见条件下的骨形成过程相关。所描述的牵张成骨模型表明骨形成的机制似乎适用于与骨形成相关的其他更常见的过程，包括骨折愈合和受损的骨折愈合。
The relation between physical forces and the processes of bone regeneration and healing remains incompletely understood. Gaps in understanding of these processes stem in part from models that produce inadequate amounts of new bone for study. Bone created through the use of distraction osteogenesis provides an attractive substrate for the study of mechanical forces and their effects on bone formation because this technique produces large volumes of new bone in a controlled fashion. The optimal mechanical environment in which bone formation occurs clinically has not been fully determined. In laboratory studies, however, the mechanical environment can be manipulated, and resultant changes in bone formation can be measured. To investigate how changes in strain environment influence patterns of bone formation, a bilateral distraction osteogenesis was implemented. When a stiffener was applied to the external distractor, computation analyses predicted a sevenfold to eightfold decrease in all strain measures. These reductions in gap strains appeared to induce significant decreases in bone volume fraction and mean trabecular thickness. When osteotomies were created at a 30° angle to the bony axis to generate more shear within the gap tissue, changes in the distribution of gap strains and resultant new bone architecture were observed. Specific correlations between changes in tissue level strains and the pattern of bone regeneration were seen in both experiments. These results provide direct in vivo evidence that pluripotential gap tissues are sensitive to their physical surroundings. Mechanisms responsible for this sensitivity might include vascularity, stem cell supply, and scaffolding architecture. The process of bone formation in distraction osteogenesis appears to be related to bone formation processes associated with more common conditions. The distraction osteogenesis model described suggests a mechanism for bone formation that seems applicable to other more common processes associated with bone formation, including fracture healing and impaired fracture healing.
登录
查看更多内容
影响因子：
2.4
作者：
GOULET, RW;GOLDSTEIN, SA;FELDKAMP, LA
通讯作者：
FELDKAMP, LA
间隙应变的减少会导致注意力分散期间骨再生的变化。
DOI：
10.1115/1.2798331
发表时间：
1999
期刊：
Journal of biomechanical engineering
影响因子：
--
作者：
Richards,M;Waanders,NA;Weiss,JA;Bhatia,V;Senunas,LE;Schaffler,MB;Goldstein,SA;Goulet,JA
通讯作者：
Goulet,JA
通过特定频率、低幅度的机械应变促进骨向内生长。
影响因子：
4.2
作者：
Rubin,CT;McLeod,KJ
通讯作者：
McLeod,KJ
影响因子：
2.4
作者：
CARTER, DR
通讯作者：
CARTER, DR
通过单平面或两平面外固定稳定胫骨截骨的早期愈合。
DOI：
--
发表时间：
1987
期刊：
The Journal of bone and joint surgery. American volume
影响因子：
--
作者：
Williams,EA;Rand,JA;An,KN;Chao,EY;Kelly,PJ
通讯作者：
Kelly,PJ