Diurnal blood pressure pattern and cardiac damage in hypertensive patients with primary aldosteronism
Diurnal blood pressure pattern and cardiac damage in hypertensive patients with primary aldosteronism
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原发性醛固酮增多症高血压患者的昼夜血压模式和心脏损害。
DOI：
10.1007/s12020-021-02606-3
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发表时间：
2021-01
期刊：
影响因子：
--
通讯作者：
Jiguang Wang
中科院分区：
文献类型：
--
作者：
Qihong Wu;Mona Hong;Jianzhong Xu;Xiaofeng Tang;Linmin Zhu;Pingjin Gao;Jiguang Wang
目的本研究的目的是评估24小时血压（BP）曲线，原发性醛固酮增多症（PA）患者与原发性高血压（EH）患者比较血浆NT-proBNP水平和左心室肥厚（LVH）。根据年龄、性别、体重指数（BMI）、血压值和高血压病程匹配385例EH患者。24小时动态血压监测（ABPM），血浆水平的NT-proBNP，左心室质量指数（LVMI），和其他临床医疗数据进行了评估，在所有patients.ResultsNo差异，年龄，性别，BMI，临床血压，24小时平均血压，白天血压，或高血压的持续时间组之间被发现。PA组夜间收缩压（130 ± 16 vs. 127 ± 17 mmHg，p< 0.05）和舒张压（82 ± 10 vs. 79 ± 11 mmHg，p< 0.01）高于EH组。此外，PA患者夜间血压下降幅度减小，而中位NT-proBNP（53.7 vs. 33.2 pg/ml，P< 0.001）和LVMI（113 ± 25 vs. 102 ± 26 g/m2，P< 0.001）高于EH患者。阿帕组NT-proBNP水平中位数（68.0 pg/ml）高于IHA组（42.4 pg/ml）（P< 0.001）。多元逐步回归分析显示，PA患者LVMI与NT-proBNP、夜间收缩压及性别相关。此外，夜间收缩压升高与PA患者的心脏损害密切相关。
PurposeThe aim of our study was to evaluate the relationship between the 24-h blood pressure (BP) profile, plasma NT-proBNP levels and left ventricular hypertrophy (LVH) in subjects with primary aldosteronism (PA) compared to patients with essential hypertension (EH).MethodsA total of 385 consecutive patients with PA [187 with aldosterone producing adenoma (APA) and 198 with idiopathic hyperaldosteronism (IHA)] and 385 patients with EH were matched based on age, sex, body mass index (BMI), BP values and duration of hypertension. Twenty-four-hour ambulatory BP monitoring (ABPM), plasma levels of NT-proBNP, left ventricular mass index (LVMI), and other clinical medical data were assessed in all patients.ResultsNo differences in age, sex, BMI, clinical BP, 24-h mean BP, daytime BP, or duration of hypertension were found between groups. Nighttime systolic BP (130 ± 16 vs. 127 ± 17 mmHg,p< 0.05) and diastolic BP (82 ± 10 vs. 79 ± 11 mmHg,p< 0.01) were higher in PA patients than in EH patients. In addition, nocturnal BP decline was reduced, while median NT-proBNP (53.7 vs. 33.2 pg/ml,P< 0.001) and LVMI (113 ± 25 vs. 102 ± 26 g/m2,P< 0.001) were higher in PA patients than in EH patients. Moreover, the median NT-proBNP level was higher in APA patients than in IHA patients (68.0 vs. 42.4 pg/ml,P< 0.001). In stepwise multivariate regression analysis, LVMI was correlated with NT-proBNP, nighttime systolic BP and sex in PA patients.ConclusionsPatients with PA show higher nighttime BP and NT-proBNP levels and lower nocturnal BP decline than those with EH. In addition, higher nocturnal systolic BP has been shown to be strongly associated with cardiac damage in PA patients.
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DOI：
10.1111/jch.12551
发表时间：
2015-08
期刊：
The Journal of Clinical Hypertension
影响因子：
--
作者：
A. Grillo;S. Bernardi;A. Rebellato;B. Fabris;M. Bardelli;J. Burrello;F. Rabbia;F. Veglio;F. Fallo;R. Carretta
通讯作者：
A. Grillo;S. Bernardi;A. Rebellato;B. Fabris;M. Bardelli;J. Burrello;F. Rabbia;F. Veglio;F. Fallo;R. Carretta
影响因子：
8.3
作者：
Savard, Sebastien;Amar, Laurence;Steichen, Olivier
通讯作者：
Steichen, Olivier
DOI：
--
发表时间：
2018
期刊：
--
影响因子：
--
作者：
Y. Zhai;Xin Chen;Xin Liu;Zhi-qiang Zhang;H. Xiao;Gang Liu
通讯作者：
Y. Zhai;Xin Chen;Xin Liu;Zhi-qiang Zhang;H. Xiao;Gang Liu
影响因子：
8.3
作者：
G. Mansoor;W. White
通讯作者：
G. Mansoor;W. White
影响因子：
4.9
作者：
O'Flynn, Anne Marie;Dolan, Eamon;Kearney, Patricia M.
通讯作者：
Kearney, Patricia M.