One-Pot Hydrothermal Synthesis of Benzalkonium-Templated Mesostructured Silica Antibacterial Agents.
One-Pot Hydrothermal Synthesis of Benzalkonium-Templated Mesostructured Silica Antibacterial Agents.
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苯并核介质的二氧化硅抗菌剂的一锅水热合成。
DOI：
10.1021/jacs.8b04843
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发表时间：
2018-10-24
影响因子：
15
通讯作者：
Asefa T
中科院分区：
文献类型：
--
作者：
Dubovoy V;Ganti A;Zhang T;Al-Tameemi H;Cerezo JD;Boyd JM;Asefa T
合成了新型介观结构二氧化硅微粒，并对其进行了表征和研究，作为药物递送系统（DDS）用于抗菌应用。该材料表现出相对高密度（0.56 g/1 g SiO2）的BAC、18 μ m宽的孔道和高表面积（1500 m2/g）。SAXRD图谱与BJH孔径分布数据的比较表明，18个纳米孔具有短程有序性，孔壁厚度约为100 nm。12英里。药物释放研究表明，BAC的pH响应控制释放，而无需额外的材料表面改性。使用幂律（Korsmeyer-Peppas）模型分析延长的药物释放数据，表明酸性（pH 4.0、5.0、6.5）溶液与中性（pH 7.4）溶液中的释放机制存在显著差异。微生物测定表明，金黄色葡萄球菌和肠道沙门氏菌活力分别在10和130 mg L−1以上的合成材料中显着降低。与对照样品相比，细胞活力随时间降低。这些发现将有助于扩大BAC作为消毒剂和杀菌剂的使用，特别是在革兰氏阳性和革兰氏阴性细菌污染常见的制药和食品行业。
Novel mesostructured silica microparticles are synthesized, characterized and investigated as a drug delivery system (DDS) for antimicrobial applications. The materials exhibit relatively high density (0.56 g per 1 g SiO2) of BAC, pore channels of 18 Å in width, and high surface area (1500 m2/g). Comparison of SAXRD pattern with BJH pore size distribution data suggests that the 18 Å pores exhibit short range ordering and a wall thickness of ca. 12 Å. Drug release studies demonstrate pH-responsive controlled release of BAC without additional surface modification of the materials. Prolonged drug release data was analyzed using a power law (Korsmeyer-Peppas) model and indicates substantial differences in release mechanism in acidic (pH 4.0, 5.0, 6.5) versus neutral (pH 7.4) solutions. Microbiological assays demonstrate a significant time-dependent reduction in Staphylococcus aureus and Salmonella enterica viability above 10 and 130 mg L−1 of the synthesized materials, respectively. The viability of cells is reduced over time compared to control samples. The findings will help in widening the use of BAC as a disinfectant and bactericidal agent, especially in pharmaceutical and food industries where Gram-positive and Gram-negative bacterial contamination is common.
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影响因子：
1.1
作者：
Dement'eva, O. V.;Roumyantseva, T. B.;Rudoy, V. M.
通讯作者：
Rudoy, V. M.
影响因子：
1.1
作者：
Dement'eva, O. V.;Senchikhin, I. N.;Rudoy, V. M.
通讯作者：
Rudoy, V. M.
影响因子：
2.3
作者：
Qu, Fengyu;Zhu, Guangshan;Qiu, Shilun
通讯作者：
Qiu, Shilun
影响因子：
13.3
作者：
Lu, Jie;Liong, Monty;Li, Zongxi;Zink, Jeffrey I.;Tamanoi, Fuyuhiko
通讯作者：
Tamanoi, Fuyuhiko
影响因子：
4.9
作者：
Furi, Leonardo;Ciusa, Maria Laura;Oggioni, Marco Rinaldo
通讯作者：
Oggioni, Marco Rinaldo