Plasma klotho and cardiovascular disease in adults.
Plasma klotho and cardiovascular disease in adults.
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DOI：
10.1111/j.1532-5415.2011.03558.x
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发表时间：
2011-09
影响因子：
6.3
通讯作者：
Ferrucci L
中科院分区：
文献类型：
--
作者：
Semba RD;Cappola AR;Sun K;Bandinelli S;Dalal M;Crasto C;Guralnik JM;Ferrucci L
为了确定血浆klotho，一种最近发现的与动脉粥样硬化有关的激素，是否与成人流行的心血管疾病有关。横截面。居住在意大利托斯卡纳的成年人的基于人口的样本。1023名年龄在24-102岁之间的男性和女性参与了基安蒂的Invecchiare（InCHIANTI）研究。人体测量、血浆klotho、空腹血浆总量、高密度脂蛋白（HDL）胆固醇、甘油三酯、葡萄糖、肌酐、C反应蛋白。临床措施：医学评估、糖尿病、高血压、冠心病、心力衰竭、中风、外周动脉疾病、癌症、慢性肾病。Logistic回归模型被用来研究血浆klotho和流行的心血管疾病之间的关系。在1023名参与者中，259名（25.3%）患有心血管疾病。中位（第25百分位数，第75百分位数）血浆klotho浓度为676（530，819）pg/mL。血浆klotho与年龄（r =-0.14，P <0.0001）、HDL胆固醇（r = 0.11，P = 0.0004）、C反应蛋白（r =-0.10，P = 0.0008）相关，但与收缩压、空腹血糖或肾功能无关。血浆klotho年龄校正几何平均值（95%置信区间[C.I.]）在有心血管疾病的参与者中为626（601，658）pg/mL，在无心血管疾病的参与者中为671（652，692）pg/mL（P = 0.0001）。校正传统的心血管风险因素（年龄、性别、吸烟、总胆固醇、HDL胆固醇、收缩压和糖尿病）后，log血浆klotho与心血管疾病的患病率相关（每增加1个标准差的比值比= 0.85，95% CI）。0.72，0.99）。在社区居住的成年人中，较高的血浆klotho浓度与患心血管疾病的可能性较低独立相关。
To determine whether plasma klotho, a recently discovered hormone that has been implicated in atherosclerosis, is related to prevalent cardiovascular disease in adults. Cross-sectional. Population-based sample of adults residing in Tuscany, Italy. One thousand and twenty-three men and women, aged 24–102, participating in the Invecchiare in Chianti (InCHIANTI) study. Anthropometric measures, plasma klotho, fasting plasma total, high-density lipoprotein (HDL) cholesterol, triglycerides, glucose, creatinine, C-reactive protein. Clinical measures: medical assessment, diabetes mellitus, hypertension, coronary heart disease, heart failure, stroke, peripheral artery disease, cancer, chronic kidney disease. Logistic regression models were used to examine the relationship between plasma klotho and prevalent cardiovascular disease. Of 1023 participants, 259 (25.3%) had cardiovascular disease. Median (25th, 75th percentile) plasma klotho concentrations were 676 (530, 819) pg/mL. Plasma klotho was correlated with age (r = −0.14, P <0.0001), HDL cholesterol (r = 0.11, P = 0.0004), C-reactive protein (r = −0.10, P = 0.0008), but not systolic blood pressure, fasting plasma glucose, or renal function. Plasma klotho age-adjusted geometric means (95% Confidence Interval [C.I.]) were 626 (601, 658) in participants with cardiovascular disease and 671 (652, 692) pg/mL in those without cardiovascular disease (P = 0.0001). Adjusting for traditional cardiovascular risk factors (age, sex, smoking, total cholesterol, HDL cholesterol, systolic blood pressure, and diabetes), log plasma klotho was associated with prevalent cardiovascular disease (Odds Ratio per 1 standard deviation increase = 0.85, 95% C.I. 0.72, 0.99). In community-dwelling adults, higher plasma klotho concentrations are independently associated with a lower likelihood of having cardiovascular disease.
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DOI：
10.1111/j.1532-5415.2000.tb03873.x
发表时间：
2000-12-01
影响因子：
6.3
作者：
Ferrucci, L;Bandinelli, S;Guralnik, JM
通讯作者：
Guralnik, JM
DOI：
10.1006/bbrc.1997.8019
发表时间：
1998-01-26
影响因子：
3.1
作者：
Matsumura, Y;Aizawa, H;Nabeshima, Y
通讯作者：
Nabeshima, Y
影响因子：
56.9
作者：
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Kuro-o, M
DOI：
10.1254/jjp.89.149
发表时间：
2002-06-01
期刊：
JAPANESE JOURNAL OF PHARMACOLOGY
影响因子：
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作者：
Nakamura, T;Saito, Y;Kurabayashi, M
通讯作者：
Kurabayashi, M
影响因子：
2.5
作者：
Kim, Younyoung;Kim, Jin-Hyuck;Lee, Chaeyoung
通讯作者：
Lee, Chaeyoung