Behavioural Economics to Improve Antihypertensive Therapy Adherence (BETA): protocol for a pilot randomised controlled trial in Los Angeles.
Behavioural Economics to Improve Antihypertensive Therapy Adherence (BETA): protocol for a pilot randomised controlled trial in Los Angeles.
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行为经济学提高抗高血压治疗依从性（BETA）：洛杉矶一项试点随机对照试验的方案。
DOI：
10.1136/bmjopen-2022-066101
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发表时间：
2023-01-25
期刊：
影响因子：
2.9
通讯作者：
中科院分区：
文献类型：
--
作者：
不依从降压治疗是降低心血管疾病风险的主要障碍之一。一些干预措施针对更高的药物依从性，但大多数并没有导致持续的依从性。习惯化已经成为缓解这一问题的一种潜在方法，但在相对较长的习惯形成阶段需要高度的动力。这项试点随机对照试验旨在测试基于行为经济学的激励措施和短信的可行性、可接受性和初步疗效，以支持服药行为的规范化，促进长期服药依从性。本研究将招募60名在洛杉矶Cedars-Sinai医疗中心寻求高血压治疗的成年患者，并以1：1：1的比例将其随机分配到三组之一：对照组（n=20）、消息组（n=20）和激励组（n=20）。所有参与者都将收到关于服药重要性的信息，并将选择一个现有的行为常规（“锚”），他们将把服药与之联系起来，并选择相应的时间。此外，消息组的参与者将每天收到短信，提醒他们日常工作的重要性，而激励组的参与者将每天收到短信和有条件的抽奖。干预措施将在三个月内实施。参与者将在干预后接受为期六个月的随访，以衡量行为持续性。将在基线、第3个月和第9个月访视时进行调查。主要结果包括：（1）干预期间和（2）干预后期间电子测量的平均药物依从性;（3）干预期间和（4）干预后期间基于参与者锚时间的平均及时药物依从性。该研究已获得Cedars-Sinai机构审查委员会的批准（研究ID：Pro 00057764）。研究结果将发表在同行评审的科学期刊上。NCT 04029883。
Non-adherence to antihypertensive therapy is one of the major barriers to reducing the risk of cardiovascular disease. Several interventions have targeted higher medication adherence, yet most do not result in sustained adherence. Routinisation has emerged as a potential method for mitigating this problem, but requires high motivation during the relatively long habit formation phase. This pilot randomised controlled trial aims to test the feasibility, acceptability, and preliminary efficacy of behavioural economics-based incentives and text messages to support the routinisation of the medication-taking behaviour for promoting long-term medication adherence. This study will recruit and randomly assign 60 adult patients seeking care for hypertension at the Cedars-Sinai Medical Center in Los Angeles to one of the three groups, Control (n=20), Messages (n=20) and Incentives (n=20) in a 1:1:1 ratio. All participants will receive information about the importance of routinisation and will select an existing behavioural routine (‘anchor’) to which they will tie their pill-taking to, and the corresponding time. Additionally, participants in the Messages group will receive daily text messages reminding them of the importance of routines, while those in the Incentives group will receive daily text messages and conditional prize drawings. The interventions will be delivered over three months. Participants will be followed for six months post-intervention to measure behavioural persistence. Surveys will be administered at baseline, month-3 and month-9 visits. Primary outcomes include: (1) electronically measured mean medication adherence during the intervention period and (2) post-intervention period; and (3) mean timely medication adherence based around the time of the participants’ anchor during the intervention period, and (4) post-intervention period. The study was approved by the Cedars-Sinai Institutional Review Board (Study ID: Pro00057764). Findings will be published in scientific peer-reviewed journals. NCT04029883.
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