Contributions of Cerebellar White Matter Microstructure to Social Difficulty in Nonverbal Learning Disability.
Contributions of Cerebellar White Matter Microstructure to Social Difficulty in Nonverbal Learning Disability.
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DOI：
10.1007/s12311-021-01265-4
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发表时间：
2021-12
期刊：
影响因子：
--
通讯作者：
Margolis AE
中科院分区：
文献类型：
--
作者：
Ramphal B;Pagliaccio D;Thomas LV;He X;Margolis AE
新出现的证据表明，小脑可能有助于各种认知能力，包括社会认知。非语言学习障碍（NVLD）的特征是视觉空间和社会障碍。最近的功能性神经影像学研究表明，NVLD儿童小脑静息状态功能连接改变，这与各种症状领域有关。然而，人们对NVLD的小脑白色物质微观结构以及它是否导致社交缺陷知之甚少。27例儿童（12例NVLD; 15例典型发育（TD））提供了可用的弥散张量成像数据。基于束的空间统计（TBSS）被用来量化分数各向异性（FA）在小脑脚。父母完成了儿童行为检查表，提供了社会困难的衡量标准。NVLD儿童的左、右小脑下脚各向异性分数更大。此外，右小脑下脚FA与儿童行为量表社会问题子量表测量的社会障碍有关。最后，NVLD诊断和更大的社会功能障碍之间的关联是由右小脑下脚FA介导的。这些发现提供了额外的证据，小脑有助于社会认知和NVLD的病理生理学。
Emerging evidence suggests that the cerebellum may contribute to variety of cognitive capacities, including social cognition. Nonverbal learning disability (NVLD) is characterized by visual-spatial and social impairment. Recent functional neuroimaging studies have shown that children with NVLD have altered cerebellar resting state functional connectivity, which is associated with various symptom domains. However, little is known about cerebellar white matter microstructure in NVLD and whether it contribute to social deficits. Twenty-seven children (12 with NVLD; 15 typically developing (TD)) contributed useable diffusion tensor imaging data. Tract-based spatial statistics (TBSS) were used to quantify fractional anisotropy (FA) in the cerebellar peduncles. Parents completed the Child Behavior Checklist, providing a measure of social difficulty. Children with NVLD had greater fractional anisotropy in the left and right inferior cerebellar peduncle. Furthermore, right inferior cerebellar peduncle FA was associated with social impairment as measured by the Child Behavior Checklist Social Problems subscale. Finally, the association between NVLD diagnoses and greater social impairment was mediated by right inferior cerebellar peduncle FA. These findings provide additional evidence that the cerebellum contributes both to social cognition and to the pathophysiology of NVLD.
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影响因子：
2.5
作者：
He X;Liu W;Li X;Li Q;Liu F;Rauh VA;Yin D;Bansal R;Duan Y;Kangarlu A;Peterson BS;Xu D
通讯作者：
Xu D
影响因子：
4.6
作者：
Heleven, Elien;van Dun, Kim;Van Overwalle, Frank
通讯作者：
Van Overwalle, Frank
影响因子：
2.4
作者：
Margolis, Amy E.;Pagliaccio, David;Marsh, Rachel
通讯作者：
Marsh, Rachel
影响因子：
4.2
作者：
DMello, Anila M.;Crocetti, Deana;Mostofsky, Stewart H.;Stoodley, Catherine J.
通讯作者：
Stoodley, Catherine J.
影响因子：
3.5
作者：
Banker SM;Pagliaccio D;Ramphal B;Thomas L;Dranovsky A;Margolis AE
通讯作者：
Margolis AE