Altered structure and functional connectivity of the hippocampus are associated with social and mathematical difficulties in nonverbal learning disability.
Altered structure and functional connectivity of the hippocampus are associated with social and mathematical difficulties in nonverbal learning disability.
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DOI：
10.1002/hipo.23264
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发表时间：
2021-01
期刊：
影响因子：
3.5
通讯作者：
Margolis AE
中科院分区：
文献类型：
--
作者：
Banker SM;Pagliaccio D;Ramphal B;Thomas L;Dranovsky A;Margolis AE
众所周知，海马体在多种复杂能力中发挥着关键作用，包括视觉空间推理、社会功能和数学。非语言学习障碍（NVLD）是一种以视觉空间推理缺陷为特征的神经发育障碍，伴随着社会功能或数学以及运动或执行功能技能的损害。尽管海马支持的行为与NVLD损伤之间存在重叠，但尚未对NVLD中海马的结构和功能进行研究。为了解决文献中的这一空白，我们首先比较了NVLD儿童（n = 24）和典型发育（TD）儿童（n = 20）的海马体积和静息状态功能连通性。然后，我们探索了海马体结构、连通性和空间、社会和数学能力的表现之间的联系。与TD儿童相比，患有NVLD的儿童左海马体积显著减少，海马-小脑连通性增强。在患有NVLD的儿童中，海马体积减少与较差的数学问题解决能力有关。虽然NVLD儿童比TD儿童表现出更多的社会问题（社会反应量表[SRS]）和更高的海马-小脑连通性，但更大的连通性与NVLD儿童而非TD儿童的社会问题较少相关。这种效应可能暗示了一种补偿机制。海马体的这些结构和功能改变可能会破坏其通过认知映射组织概念框架的假定作用，从而导致NVLD特征的跨域困难。
The hippocampus is known to play a critical role in a variety of complex abilities, including visual-spatial reasoning, social functioning, and math. Nonverbal Learning Disability (NVLD) is a neurodevelopmental disorder characterized by deficits in visual-spatial reasoning that are accompanied by impairment in social function or mathematics, as well as motor or executive function skills. Despite the overlap between behaviors supported by the hippocampus and impairments in NVLD, the structure and function of the hippocampus in NVLD has not been studied. To address this gap in the literature, we first compared hippocampal volume and resting-state functional connectivity in children with NVLD (n = 24) and typically developing (TD) children (n = 20). We then explored associations between hippocampal structure, connectivity, and performance on measures of spatial, social, and mathematical ability. Relative to TD children, those with NVLD showed significant reductions in left hippocampal volume and greater hippocampal-cerebellar connectivity. In children with NVLD, reduced hippocampal volume associated with worse mathematical problem solving. Although children with NVLD exhibited more social problems (Social Responsiveness Scale [SRS]) and higher hippocampal-cerebellar connectivity relative to TD children, greater connectivity was associated with fewer social problems among children with NVLD but not TD children. Such an effect may suggest a compensatory mechanism. These structural and functional alterations of the hippocampus may disrupt its putative role in organizing conceptual frameworks through cognitive mapping, thus contributing to the cross-domain difficulties that characterize NVLD.
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影响因子：
16.2
作者：
Eichenbaum H;Cohen NJ
通讯作者：
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影响因子：
4.6
作者：
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DOI：
10.1093/cercor/bhw417
发表时间：
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期刊：
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影响因子：
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作者：
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影响因子：
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作者：
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