H.M., Word Knowledge, and Aging: upport for a New Theory of Long-Term Retrograde Amnesia
H.M., Word Knowledge, and Aging: upport for a New Theory of Long-Term Retrograde Amnesia
复制标题
H.M.,单词知识和衰老:支持长期逆行性遗忘症的新理论
DOI:
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发表时间:
2001
期刊:
影响因子:
--
通讯作者:
D. G. MacKay
中科院分区:
文献类型:
--
作者:
L. E. James;D. G. MacKay
This study develops a new theory of long-term retrograde amnesia that encompasses episodic and semantic memory, including word knowledge. Under the theory, retrograde amnesia in both normal individuals and hippocampal amnesics reflects transmission deficits caused by aging, nonrecent use of connections, and infrequent use of connections over the life span. However, transmission deficits cause severe and irreversible retrograde amnesia only in amnesics who (unlike normal persons) cannot readily form new connections to replace nonfunctioning ones. The results of this study are consistent with this theory: For low-frequency but not high-frequency words, a famous “hippocampal amnesic” (H.M.) at age 71 performed worse than memory-normal control participants in a lexical decision experiment and a meaning-definition task (e.g., What does squander mean?). Also as predicted, H.M.'s lexical decision performance declined dramatically between ages 57 and 71 for low-frequency words, but was age-invariant for high-frequency words.
DOI:
10.1136/jnnp.48.6.556
发表时间:
1985
期刊:
Journal of neurology, neurosurgery, and psychiatry
影响因子:
--
作者:
Levin,HS;High,WM;Meyers,CA;VonLaufen,A;Hayden,ME;Eisenberg,HM
通讯作者:
Eisenberg,HM
影响因子:
3.7
作者:
Laver,GD;Burke,DM
通讯作者:
Burke,DM