Chronic schistosomiasis during pregnancy epigenetically reprograms T‐cell differentiation in offspring of infected mothers
Chronic schistosomiasis during pregnancy epigenetically reprograms T‐cell differentiation in offspring of infected mothers
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妊娠期间的慢性血吸虫病会在表观遗传上重新编程受感染母亲后代的 Tâcell 分化
DOI：
10.1002/eji.201646836
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发表时间：
2017
影响因子：
5.4
通讯作者：
Prazeres da Costa C
中科院分区：
文献类型：
--
作者：
Klar K;Perchermeier S;Bhattacharjee S;Harb H;Adler T;Istvanffy R;Loffredo-Verde E;Oostendorp R;Renz H;Prazeres da Costa C
血吸虫病是一种非经胎盘的蠕虫感染。妊娠期慢性感染抑制后代的过敏性气道反应。我们探讨了小鼠宫内暴露于慢性溶酶体感染（Reg期）是否会影响B细胞和T细胞发育的问题。因此，我们将分析重点放在后代中特征细胞因子启动子区的表观遗传变化诱导的T细胞分化能力上。在这里，我们发现，来自受感染的雌性小鼠后代的幼稚T细胞具有很强的分化为TH 1细胞的能力，而TH 2分化受损。因此，在幼稚T细胞中观察到IL-4启动子区域的组蛋白乙酰化水平降低。总之，我们的小鼠模型揭示了在慢性蠕虫感染母亲的后代中影响TH 2和TH 1细胞分化的幼稚T细胞区室中的明显表观遗传变化。这些发现最终可能有助于了解蠕虫如何改变由过敏原，细菌或病毒感染以及疫苗诱导的T细胞驱动的免疫反应。
Schistosomiasis is a nontransplacental helminth infection. Chronic infection during pregnancy suppresses allergic airway responses in offspring. We addressed the question whether in utero exposure to chronic schistosome infection (Reg phase) in mice affects B‐cell and T‐cell development. Therefore, we focused our analyses on T‐cell differentiation capacity induced by epigenetic changes in promoter regions of signature cytokines in offspring. Here, we show that naïve T cells from offspring of schistosome infected female mice had a strong capacity to differentiate into TH1 cells, whereas TH2 differentiation was impaired. In accordance, reduced levels of histone acetylation of the IL‐4 promoter regions were observed in naïve T cells. To conclude, our mouse model revealed distinct epigenetic changes within the naïve T‐cell compartment affecting TH2 and TH1 cell differentiation in offspring of mothers with chronic helminth infection. These findings could eventually help understand how helminths alter T‐cell driven immune responses induced by allergens, bacterial or viral infections, as well as vaccines.
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影响因子：
14.2
作者：
H. Smits;C. Akdis
通讯作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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影响因子：
4.4
作者：
C. Lima;V. Souza;E. Faquim;M. Hoshida;E. Bevilacqua;M. Macedo;W. Tavares;B. Vargaftig
通讯作者：
B. Vargaftig
DOI：
10.1084/jem.20090845
发表时间：
2009-12-21
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Conrad ML;Ferstl R;Teich R;Brand S;Blümer N;Yildirim AO;Patrascan CC;Hanuszkiewicz A;Akira S;Wagner H;Holst O;von Mutius E;Pfefferle PI;Kirschning CJ;Garn H;Renz H
通讯作者：
Renz H