Adjusting vascular permeability, leukocyte infiltration, and microglial cell activation to rescue dopaminergic neurons in rodent models of Parkinson's disease.
Adjusting vascular permeability, leukocyte infiltration, and microglial cell activation to rescue dopaminergic neurons in rodent models of Parkinson's disease.
复制标题
DOI：
10.1038/s41531-021-00233-3
复制
发表时间：
2021-10-08
期刊：
影响因子：
--
通讯作者：
Han S
中科院分区：
文献类型：
--
作者：
Cai HY;Fu XX;Jiang H;Han S
Animal studies have indicated that increased blood-brain barrier (BBB) permeability and inflammatory cell infiltration are involved during the progression of Parkinson’s disease (PD). This study used C16, a peptide that competitively binds to integrin αvβ3 and inhibits inflammatory cell infiltration, as well as angiopoietin-1 (Ang-1), an endothelial growth factor crucial for blood vessel protection, to reduce inflammation and improve the central nervous system (CNS) microenvironment in murine models of PD. The combination of C16 and Ang-1 yielded better results compared to the individual drugs alone in terms of reducing dopaminergic neuronal apoptosis, ameliorating cognitive impairment, and electrophysiological dysfunction, attenuating inflammation in the CNS microenvironment, and improving the functional disability in PD mice or rats. These results suggest neuroprotective and anti-inflammatory properties of the C16 peptide plus Ang-1 in PD.
登录
查看更多内容
影响因子：
4.6
作者：
Han S;Zhang F;Hu Z;Sun Y;Yang J;Davies H;Yew DT;Fang M
通讯作者：
Fang M
影响因子：
14.8
作者：
Jackson-Lewis, Vernice;Przedborski, Serge
通讯作者：
Przedborski, Serge
加兰他敏改善小鼠认知、海马炎症和脂多糖引起的突触可塑性损伤
影响因子：
9.3
作者：
Liu Y;Zhang Y;Zheng X;Fang T;Yang X;Luo X;Guo A;Newell KA;Huang XF;Yu Y
通讯作者：
Yu Y
影响因子：
3.9
作者：
Lin, Chin-Hsien;Liu, Huei-Chun;Chiu, Ming-Jang
通讯作者：
Chiu, Ming-Jang
影响因子：
4.6
作者：
Zhang Y;Tian K;Jiang H;Wang B;Han S
通讯作者：
Han S