Long-Term Post-COVID-19 Associated Oral Inflammatory Sequelae.
Long-Term Post-COVID-19 Associated Oral Inflammatory Sequelae.
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DOI：
10.3389/fcimb.2022.831744
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发表时间：
2022
影响因子：
5.7
通讯作者：
Jabra-Rizk MA
中科院分区：
文献类型：
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作者：
Alfaifi A;Sultan AS;Montelongo-Jauregui D;Meiller TF;Jabra-Rizk MA
尽管在Covid-19患者中观察到的无数口腔条件，但在唾液上皮细胞中发现了sars-cov-2的基础。 ，Hisstatin-5专门生产唾液腺在天生的免疫学中起着至关重要的作用，反对殖民地的腺体-2造成了Hisstatin-5的销毁，而Hisstatin-5则强烈地表明，在这里，您会及时介绍Hisstatin-5的生产背后的生理机制症状，我们分析了组织5和关键细胞因子的患者和健康受试者的唾液样本，这显着降低了患者的唾液中的Histatin-5水平，并激活TH17炎症途径。根据历史和唾液分析，表现出明显降低的抗糖体效率，假设唾液histatin-5的产生可能会因SARS-COV-2介导的唾液腺破坏而受到损害。 ucosal急性ILL和恢复Covid-19患者的炎症过程。
The oral cavity remains an underappreciated site for SARS-CoV-2 infection despite the myriad oral conditions observed in COVID-19 patients. Recently, replicating SARS-CoV-2 was found inside salivary epithelial cells resulting in inflammation and atrophy of salivary glands. Saliva possesses healing properties crucial for maintaining the health of the oral mucosa. Specifically, salivary antimicrobial peptides, most notable, histatin-5 exclusively produced in salivary glands, plays a vital role in innate immunity against colonizing microbial species. The demonstration of SARS-CoV-2 destruction of gland tissue where histatin-5 is produced strongly indicate that histatin-5 production is compromised due to COVID-19. Here we present a case of a patient presenting with unexplained chronic oral dysesthesia and dysgeusia post-recovery from COVID-19. To explore potential physiological mechanisms behind the symptoms, we comparatively analyzed saliva samples from the patient and matched healthy subject for histatin-5 and key cytokines. Findings demonstrated significantly reduced histatin-5 levels in patient’s saliva and activation of the Th17 inflammatory pathway. As histatin-5 exhibits potent activity against the opportunistic oral pathogen Candida albicans, we evaluated saliva potency against C. albicans ex vivo. Compared to control, patient saliva exhibited significantly reduced anti-candidal efficacy. Although speculative, based on history and salivary analysis we hypothesize that salivary histatin-5 production may be compromised due to SARS-CoV-2 mediated salivary gland destruction. With the current lack of emphasis on implications of COVID-19 on oral health, this report may provide lacking mechanistic insights that may lead to reassessment of risks for oral opportunistic infections and mucosal inflammatory processes in acutely-ill and recovered COVID-19 patients.
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影响因子：
6
作者：
Martonik D;Parfieniuk-Kowerda A;Rogalska M;Flisiak R
通讯作者：
Flisiak R
评估白介素-23/17轴在危重患病患者中的作用。
影响因子：
--
作者：
Jahaj E;Vassiliou AG;Keskinidou C;Gallos P;Vrettou CS;Tsipilis S;Mastora Z;Orfanos SE;Dimopoulou I;Kotanidou A
通讯作者：
Kotanidou A
影响因子：
4.6
作者：
Mardani M;Mofidi H;Dastgheib L;Ranjbar S;Hamidizadeh N
通讯作者：
Hamidizadeh N
影响因子：
6.7
作者：
Peters BM;Shirtliff ME;Jabra-Rizk MA
通讯作者：
Jabra-Rizk MA
影响因子：
--
作者：
Nguyen, Cuong Q.;Hu, Min H.;Peck, Ammon B.
通讯作者：
Peck, Ammon B.