Molecular and Cellular Mechanisms of Itch in Psoriasis.
Molecular and Cellular Mechanisms of Itch in Psoriasis.
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DOI：
10.3390/ijms21218406
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发表时间：
2020-11-09
影响因子：
5.6
通讯作者：
Takamori K
中科院分区：
文献类型：
--
作者：
Komiya E;Tominaga M;Kamata Y;Suga Y;Takamori K
瘙痒（或瘙痒症）以前未被认为是银屑病的严重症状。然而，约60-90%的银屑病瘙痒患者表示，它恶化了他们的生活质量。由于传统的抗瘙痒治疗，如抗组胺药，只发挥有限的作用，建立一个治疗方案的瘙痒银屑病是迫切需要的。虽然目前尚无确定的药物，但已知各种瘙痒介质参与银屑病瘙痒。在这篇综述中，我们描述了银屑病瘙痒的临床特征，分类范围广泛的瘙痒介质的类别，如神经，免疫，内分泌和血管系统，并讨论了这些介质诱导或加重银屑病瘙痒的病理生理机制。
Itch (or pruritus) was not previously recognized as a serious symptom of psoriasis. However, approximately 60–90% of psoriatic patients with pruritus have stated that it deteriorates their quality of life. Since conventional antipruritic therapies, such as antihistamines, only exert limited effects, the establishment of a treatment option for itch in psoriasis is urgently needed. Although a definitive drug is not currently available, various itch mediators are known to be involved in pruritus in psoriasis. In this review, we describe the clinical features of pruritus in psoriasis, classify a wide range of itch mediators into categories, such as the nervous, immune, endocrine, and vascular systems, and discuss the mechanisms by which these mediators induce or aggravate itch in the pathophysiology of psoriasis.
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DOI：
10.1016/j.jaci.2016.12.980
发表时间：
2017-08
期刊：
The Journal of allergy and clinical immunology
影响因子：
--
作者：
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通讯作者：
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影响因子：
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作者：
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影响因子：
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通讯作者：
Nakaike, S
影响因子：
8.8
作者：
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通讯作者：
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影响因子：
13.8
作者：
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