Is there a causal relationship between executive function and liability to mental health and substance use? A Mendelian randomization approach.
Is there a causal relationship between executive function and liability to mental health and substance use? A Mendelian randomization approach.
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DOI：
10.1098/rsos.220631
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发表时间：
2022-12
影响因子：
3.5
通讯作者：
Reed, Zoe E.
中科院分区：
文献类型：
--
作者：
Burton, Sabrina M., I;Sallis, Hannah M.;Hatoum, Alexander S.;Munafo, Marcus R.;Reed, Zoe E.
执行功能（EF）测试任务中表现较差与一系列精神病理学有关，例如精神分裂症、重度抑郁症（MDD）和焦虑症，以及吸烟和饮酒。我们使用两个样本双向孟德尔随机化来检查这些是否可以反映因果关系和因果关系的方向。我们使用全基因组关联研究摘要数据（N = 17 310 至 848 460）来了解常见 EF 因子评分 (cEF)、精神分裂症、MDD、焦虑、开始吸烟、饮酒、酒精依赖和大麻使用障碍 (CUD)。我们发现证据表明，cEF 增加可降低精神分裂症倾向（OR = 0.10；CI：0.05 至 0.19；p 值 = 3.43 × 10−12）、MDD 倾向（OR = 0.52；CI：0.38 至 0.72；p 值 = 5.23 × 10−05）、每周饮酒量（β = –0.06；CI： –0.10 至 −0.02；p 值 = 0.003）和 CUD 责任（OR = 0.27；CI：0.12 至 0.61；p 值 = 1.58 × 10−03）。我们还发现了精神分裂症倾向增加的证据（β = -0.04；CI：-0.04 至 -0.03；p 值 = 3.25 × 10−27）和开始吸烟导致 cEF 降低（β = -0.06；CI：-0.09 至 -0.03；p 值 = 6.11 × 10−05）。我们的结果表明 cEF 与心理健康和物质使用之间存在潜在因果关系。需要进一步的研究来提高我们对这些影响的潜在机制的理解，但我们的结果表明，EF 可能是心理健康和物质使用的一个有前途的干预目标。
Poorer performance in tasks testing executive function (EF) is associated with a range of psychopathologies such as schizophrenia, major depressive disorder (MDD) and anxiety, as well as smoking and alcohol consumption. We used two-sample bidirectional Mendelian randomization to examine whether these may reflect causal relationships and the direction of causation. We used genome-wide association study summary data (N = 17 310 to 848 460) for a common EF factor score (cEF), schizophrenia, MDD, anxiety, smoking initiation, alcohol consumption, alcohol dependence and cannabis use disorder (CUD). We found evidence of increased cEF on reduced schizophrenia liability (OR = 0.10; CI: 0.05 to 0.19; p-value = 3.43 × 10−12), MDD liability (OR = 0.52; CI: 0.38 to 0.72; p-value = 5.23 × 10−05), drinks per week (β = –0.06; CI: –0.10 to −0.02; p-value = 0.003) and CUD liability (OR = 0.27; CI: 0.12 to 0.61; p-value = 1.58 × 10−03). We also found evidence of increased schizophrenia liability (β = −0.04; CI: −0.04 to −0.03; p-value = 3.25 × 10−27) and smoking initiation on decreased cEF (β = −0.06; CI: −0.09 to −0.03; p-value = 6.11 × 10−05). Our results indicate potential causal relationships between cEF and mental health and substance use. Further studies are required to improve our understanding of the underlying mechanisms of these effects, but our results suggest that EF may be a promising intervention target for mental health and substance use.
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影响因子：
7.7
作者：
Bowden J;Del Greco M F;Minelli C;Davey Smith G;Sheehan NA;Thompson JR
通讯作者：
Thompson JR
影响因子：
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作者：
Bowden J;Davey Smith G;Haycock PC;Burgess S
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通讯作者：
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