Fatty acid ethanolamide levels are altered in borderline personality and complex posttraumatic stress disorders
Fatty acid ethanolamide levels are altered in borderline personality and complex posttraumatic stress disorders
复制标题
脂肪酸乙醇酰胺水平在边缘人格和复杂的创伤后应激障碍中发生改变
DOI：
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发表时间：
2014
影响因子：
4.7
通讯作者：
F. Leweke
中科院分区：
文献类型：
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作者：
Carola Schaefer;Carola Schaefer;F. Enning;Juliane K. Mueller;J. Bumb;Cathrin Rohleder;T. Odorfer;J. Klosterkötter;M. Hellmich;D. Koethe;C. Schmahl;M. Bohus;F. Leweke
摘要
边缘人格(BPD)和复杂的创伤后应激障碍(PTSD)都与儿童和青少年时期的人际暴力经历密切相关。这些疾病经常并存，并经常导致普遍存在的问题，例如，情绪调节和痛觉改变，其中内源性大麻素系统深度参与。我们假设内源性大麻素在这两种疾病中起作用。我们调查了BPD、PTSD和对照组的血清内源性大麻素和2-花生四烯酸甘油及相关脂肪酸乙醇酰胺(FAE)的水平。BPD患者的内源性大麻素和创伤后应激障碍患者的FAE油酰乙醇胺均有显著变化，提示它们分别与这两种疾病有关。
Abstract
Borderline personality (BPD) and complex posttraumatic stress disorders (PTSD) are both powerfully associated with the experience of interpersonal violence during childhood and adolescence. The disorders frequently co-occur and often result in pervasive problems in, e.g., emotion regulation and altered pain perception, where the endocannabinoid system is deeply involved. We hypothesize an endocannabinoid role in both disorders. We investigated serum levels of the endocannabinoids anandamide and 2-arachidonoylglycerol and related fatty acid ethanolamides (FAEs) in BPD, PTSD, and controls. Significant alterations were found for both endocannabinoids in BPD and for the FAE oleoylethanolamide in PTSD suggesting a respective link to both disorders.
影响因子：
--
作者：
Green, Jennifer Greif;McLaughlin, Katie A.;Berglund, Patricia A.;Gruber, Michael J.;Sampson, Nancy A.;Zaslavsky, Alan M.;Kessler, Ronald C.
通讯作者：
Kessler, Ronald C.
青春期同伴排斥持续改变雌性大鼠的疼痛感知和 CB1 受体表达
影响因子：
5.6
作者：
Schneider P;Hanusch C;Schmahl C;Bohus M;Spanagel R;Schneider M
通讯作者：
Schneider M