Adolescent peer-rejection persistently alters pain perception and CB1 receptor expression in female rats
Adolescent peer-rejection persistently alters pain perception and CB1 receptor expression in female rats
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青春期同伴排斥持续改变雌性大鼠的疼痛感知和 CB1 受体表达
DOI：
10.1016/j.euroneuro.2013.04.004
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发表时间：
2014
影响因子：
5.6
通讯作者：
Schneider M
中科院分区：
文献类型：
--
作者：
Schneider P;Hanusch C;Schmahl C;Bohus M;Spanagel R;Schneider M
同龄人之间的互动在青春期尤为重要，青少年对同龄人的拒绝表现出更高的敏感性。社会排斥已被证明会引起人类疼痛感知的改变。然而，青少年社会排斥的神经生物学后果尚未得到广泛的特点，没有合适的动物模型。在这里，我们提出青春期大鼠中不充分的玩耍互动作为社交同伴排斥的新型动物模型，并研究成年后潜在的长期后果。急性社会配对的雌性青春期Wistar大鼠与年龄匹配的大鼠从不好玩的Fischer 344株被发现改变社会发挥和减少疼痛反应，表明Fischer大鼠作为不够的社会伙伴的Wistar动物。因此，在第二个实验中，青春期雌性Wistar大鼠与另一只Wistar大鼠（充分的社会养育;对照）或Fischer大鼠（社会养育不足;游戏剥夺）一起饲养。从第50天开始，将所有Wistar大鼠与相同品系的伴侣分组饲养，并测试成年后的行为、神经生物学和内分泌差异。在被剥夺玩耍的动物中，玩耍的同伴互动在青春期减少，而不影响社会接触行为。因此，与对照组相比，成年玩耍剥夺大鼠表现出疼痛敏感性降低和惊吓反应增加，但在活动，焦虑相关行为或社会互动方面没有差异。两组在内分泌应激反应方面也不同，丘脑中大麻素CB 1受体的表达水平增加，而杏仁核中FAAH水平降低。因此，本动物模型代表了一种新的方法来评估在青春期同伴拒绝的长期后果。
Peer-interactions are particularly important during adolescence and teenagers display enhanced sensitivity toward rejection by peers. Social rejection has been shown to induce alterations in pain perception in humans. However, the neurobiological consequences of adolescent social rejection have yet to be extensively characterized, and no appropriate animal model is available. Here, we propose inadequate playful interactions in adolescent rats as a novel animal model for social peer-rejection and examine potential long-term consequences into adulthood. Acute social pairing of female adolescent Wistar rats with an age-matched rat from the less playful Fischer344 strain was found to alter social play and decrease pain reactivity, indicating Fischer rats as inadequate social partners for Wistar animals. Therefore, in a second experiment, adolescent female Wistar rats were either reared with another Wistar rat (adequate social rearing; control) or with a Fischer rat (inadequate social rearing; play-deprived). Beginning on day 50, all Wistar rats were group housed with same-strain partners and tested for behavioral, neurobiological and endocrine differences in adulthood. Playful peer-interactions were decreased during adolescence in play-deprived animals, without affecting social contact behavior. Consequently, adult play-deprived rats showed decreased pain sensitivity and increased startle reactivity compared to controls, but did not differ in activity, anxiety-related behavior or social interaction. Both groups also differed in their endocrine stress-response, and expression levels of the cannabinoid CB1 receptor were increased in the thalamus, whereas FAAH levels were decreased in the amygdala. The present animal model therefore represents a novel approach to assess the long-term consequences of peer-rejection during adolescence.
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