Adjusting the size of multicompartmental containers made of anionic liposomes and polycations by introducing branching and PEO moieties
Adjusting the size of multicompartmental containers made of anionic liposomes and polycations by introducing branching and PEO moieties
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通过引入支化和 PEO 部分来调整由阴离子脂质体和聚阳离子制成的多室容器的尺寸
DOI：
10.1016/j.polymer.2017.05.041
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发表时间：
2017
期刊：
影响因子：
4.6
通讯作者：
F. A. Plamper
中科院分区：
文献类型：
--
作者：
C. E. Pinguet;J. M. Hoffmann;A. A. Steinschulte;A. Sybachin;K. Rahimi;D. Wöll;A. Yaroslavov;W. Richtering;F. A. Plamper
我们提出了一种策略，以调整大小的多脂质体复合物的小单层阴离子脂质体（脂质双层囊泡制备的两性离子脂质1，2-二油酰基-sn-甘油-3-磷酸胆碱DOPC和离子脂质1-棕榈酰基-2-油酰基-sn-甘油-3-磷酸-l-丝氨酸POPS的典型直径为50 nm）与阳离子聚合物由于静电吸引。因此，使用季铵化聚（甲基丙烯酸二甲氨基乙酯），qPDMAEMA，允许构建多隔室载体。各种qPDMAEMA样品的结构和组成的变化证明了引入聚（环氧乙烷）PEO部分和/或支化对分级组装体的尺寸的影响：PEO嵌段（如嵌段共聚物和杂臂星所见）和支化（如星形均聚物和杂臂星所见）两者与具有线性qPDMAEMA均聚物的复合物相比导致更小的复合物。除了使用低温透射电子显微镜（cryo-TEM）外，还通过双色荧光互相关光谱（FCCS）验证了由不同负载的脂质体组成的多隔室载体的形成。
We propose a strategy to adjust the size of multiliposomal complexes made of small unilamellar anionic liposomes (lipid bilayer vesicles prepared from zwitterionic lipid 1,2-dioleoyl-sn-glycero-3-phosphocholine DOPC and ionic lipid 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-l-serine POPS with a typical diameter of 50 nm) with cationic polymers due to electrostatic attraction. Hereby, the use of quaternized poly(dimethylaminoethyl methacrylate),qPDMAEMA, allows the construction of multicompartmental carriers. Variation of the architecture and composition of variousqPDMAEMA samples demonstrates the effect of introducing poly(ethylene oxide) PEO moieties and/or branching on the size of the hierarchical assemblies: both the PEO block (as seen for block copolymers and miktoarm stars) and the branching (as seen for star-shaped homopolymers and miktoarm stars) lead to smaller complexes compared to complexes with a linearqPDMAEMA homopolymer. Besides the use of cryogenic transmission electron microscopy (cryo-TEM), the formation of multicompartmental carriers composed of differently loaded liposomes is verified by two-color fluorescence cross-correlation spectroscopy (FCCS).
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影响因子：
8.6
作者：
Weinan Xu;A. Steinschulte;F. Plamper;V. Korolovych;V. Tsukruk
通讯作者：
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DOI：
--
发表时间：
2015
期刊：
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DOI：
10.1016/j.nano.2017.02.001
发表时间：
2017
期刊：
Nanomedicine : nanotechnology, biology, and medicine
影响因子：
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作者：
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