Strengthening the GABAergic System Through Neurofeedback Training Suppresses Implicit Motor Learning
Strengthening the GABAergic System Through Neurofeedback Training Suppresses Implicit Motor Learning
复制标题
通过神经反馈训练加强 GABA 能系统抑制内隐运动学习
DOI：
10.1016/j.neuroscience.2022.02.002
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发表时间：
2022
期刊：
影响因子：
3.3
通讯作者：
Huang Ying-Zu
中科院分区：
文献类型：
--
作者：
Gyoda Tomoya;Nojima Ippei;Lin Su-Chuan;Koganemaru Satoko;Mima Tatsuya;Tanabe Shigeo;Huang Ying-Zu
初级运动皮层（M1）内的γ-氨基丁酸（GABA）活性对于皮层可塑性中的运动学习至关重要，最近的研究表明，实时神经反馈训练（NFT）可以自我调节GABA活性。因此，本研究旨在探讨通过NFT增强GABA活性对后续运动学习的影响。36名健康参与者被随机分配到NFT组或对照组，接受假反馈。使用成对脉冲经颅磁刺激评估右侧M1内的短皮质内抑制（SICI）的GABA活性。在NFT干预期间，参与者试图调整圆圈的大小，这是根据NFT组中SICI的程度而改变的。然而，在对照组中，大小的改变与SICI的程度无关。我们测量了反应时间之前，之后（在线学习），24小时后（离线学习）的手指敲击任务。结果表明，NFT干预可增强GABA活性，抑制在线学习，但不抑制离线学习。这些发现表明，先前的GABA活动调制可能会影响在线运动学习。
Gamma-aminobutyric acid (GABA) activity within the primary motor cortex (M1) is essential for motor learning in cortical plasticity, and a recent study has suggested that real-time neurofeedback training (NFT) can self-regulate GABA activity. Therefore, this study aimed to investigate the effect of GABA activity strengthening via NFT on subsequent motor learning. Thirty-six healthy participants were randomly assigned to either an NFT group or control group, which received sham feedback. GABA activity was assessed for short intracortical inhibition (SICI) within the right M1 using paired-pulse transcranial magnetic stimulation. During the NFT intervention period, the participants tried to modulate the size of a circle, which was altered according to the degree of SICI in the NFT group. However, the size was altered independently of the degree of SICI in the control group. We measured the reaction time before, after (online learning), and 24 h after (offline learning) the finger-tapping task. Results showed the strengthening of GABA activity induced by the NFT intervention, and the suppression of the online but not the offline learning. These findings suggest that prior GABA activity modulation may affect online motor learning.
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影响因子：
4.2
作者：
Blicher JU;Near J;Næss-Schmidt E;Stagg CJ;Johansen-Berg H;Nielsen JF;Østergaard L;Ho YC
通讯作者：
Ho YC
影响因子：
14.5
作者：
Ziemann, U;Muellbacher, W;Cohen, LG
通讯作者：
Cohen, LG
对初级运动皮层的经颅静态磁刺激改变了顺序隐性运动学习
影响因子：
2.5
作者：
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影响因子：
3
作者：
Alves-Pinto, Ana;Turova, Varvara;Lampe, Renee
通讯作者：
Lampe, Renee
影响因子：
2.7
作者：
D. Serrien;Michiel M. Sovijärvi
通讯作者：
Michiel M. Sovijärvi