Transcranial static magnetic stimulation over the primary motor cortex alters sequential implicit motor learning
Transcranial static magnetic stimulation over the primary motor cortex alters sequential implicit motor learning
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对初级运动皮层的经颅静态磁刺激改变了顺序隐性运动学习
DOI：
10.1016/j.neulet.2018.12.010
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发表时间：
2019
期刊：
影响因子：
2.5
通讯作者：
Mima T.
中科院分区：
文献类型：
--
作者：
Nojima I;Watanabe T;Goyda T;Sugata H;Ikeda T;Mima T.
经颅静态磁刺激（tSMS）是一种新的无创性脑刺激技术，可以调节大脑的兴奋性。在这里，我们研究了一个假设，即运动学习将被应用于初级运动皮层（M1）的tSMS改变。对于运动任务，我们选择了一个由顺序试验和随机试验组成的系列反应时任务，其中视觉线索不播放重复的位置模式来评估内隐运动学习，其中M1是技能获得和早期巩固的关键结构。44名健康的右利手志愿者参加了本研究。将TSMS置于右侧M1或背外侧前额叶皮质（DLPFC）上。对照组在右侧M1接受假刺激。在练习前和练习后分别对左手的反应时进行分析，以考察在线学习情况，并在练习24 h后对反应时进行评估，以考察离线学习情况。结果表明，无论刺激位置如何，治疗后的RT均比治疗前快。有趣的是，在Cons会话中，M1刺激的RT显著快于DLPFC或Sham刺激。在会话或刺激位置之间的错误率没有显著差异。这些发现表明，使用tSMS的M1的调制可以增强内隐任务中的离线运动学习。
Transcranial static magnetic stimulation (tSMS) is a recently introduced noninvasive brain stimulation technique that can modulate brain excitability. Here, we investigated a hypothesis that motor learning would be altered by tSMS applied to the primary motor cortex (M1). For motor task, we chose a serial reaction time task consisting of sequential trials and random trials in which the visual cue doesn’t play out a repeating pattern of positions to evaluate an implicit motor learning, where the M1 is a key structure for skill acquisition and early consolidation. Forty-four healthy right-handed volunteers participated in the present study. TSMS was placed over the right M1 or dorsolateral prefrontal cortex (DLPFC). The control group received Sham stimulation over the right M1. Reaction times (RTs) of left hand were analyzed before (Pre session) and after (Post session) practice to examine online learning, and were also assessed 24 h later to examine offline learning (Cons session). The results showed that the RTs became faster in Post than Pre session regardless of the stimulation location. Interestingly, the RTs were significantly faster with the M1 stimulation than the DLPFC or Sham stimulation in Cons session. There was not significant difference in error rate among sessions or stimulation locations. These findings suggest that the modulation of the M1 using tSMS can enhance offline motor learning in an implicit task.
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